公开(公告)号：US11472760B2

公开(公告)日：2022-10-18

申请号：US17421536

申请日：2019-01-17

Applicant: SYMRISE AG

Inventor： Tom Brunzel ,  Angela Köckritz

IPC: C07C45/34 ,  B01J23/00 ,  B01J23/44 ,  B01J23/745

Abstract: A process is proposed for preparing unsaturated macrocyclic monoketones, comprising the following steps: (a) providing macrocyclic dienes having a ring size of at least 9 carbon atoms; (b) contacting the starting materials from step (a) with (b1) a palladium(II) salt and/or a palladium(II) complex; and (b2) an oxidizing agent; and (b3) a solvent; and optionally (b4) a ligand; and optionally (b5) a co-catalyst; and optionally (b6) an acid, with the proviso that the co-catalyst (b5) comprises or consists of a divalent or trivalent iron salt which is different from FeSO4 and is preferably iron(III) nitrate.

公开(公告)号：US20220055976A1

公开(公告)日：2022-02-24

申请号：US17421536

申请日：2019-01-17

Applicant: SYMRISE AG

Inventor： Tom Brunzel ,  Angela Köckritz

IPC: C07C45/34 ,  B01J23/44 ,  B01J23/745

Abstract: A process is proposed for preparing unsaturated macrocyclic monoketones, comprising the following steps: (a) providing macrocyclic dienes having a ring size of at least 9 carbon atoms; (b) contacting the starting materials from step (a) with (b1) a palladium(II) salt and/or a palladium(II) complex; and (b2) an oxidizing agent; and (b3) a solvent; and optionally (b4) a ligand; and optionally (b5) a co-catalyst; and optionally (b6) an acid, with the proviso that the co-catalyst (b5) comprises or consists of a divalent or trivalent iron salt which is different from FeSO4 and is preferably iron(III) nitrate.

公开(公告)号：US11021426B2

公开(公告)日：2021-06-01

申请号：US16758630

申请日：2017-10-25

Applicant: Symrise AG

Inventor： Tom Brunzel ,  Angela Köckritz ,  Andreas Martin ,  Diego A. Jaime Trevino

IPC: C07C45/34 ,  B01J23/00 ,  B01J31/00 ,  B01J23/44 ,  B01J31/22 ,  C07C49/587

Abstract: A method for producing unsaturated macrocyclic monoketones comprising the following steps: (a) preparing macrocyclic dienes with a ring size of at least 9 carbon atoms; (b) contacting the starting materials from step (a) with (b1) a palladium(II) salt and/or a palladium(II) complex; and (b2) an oxidant; and (b3) a solvent; and optionally (b4) a ligand; and optionally (b5) a co-catalyst; and optionally (b6) an acid.