公开(公告)号：US11053188B2

公开(公告)日：2021-07-06

申请号：US16764666

申请日：2018-11-14

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Raphael Dumeunier ,  Tomas Smejkal ,  Brijnandan Premnath Mishra ,  Vijayagopal Raman Gopalsamuthiram ,  Edouard Godineau ,  Anthony Cornelius O'Sullivan

IPC: C07C231/06 ,  C07C45/44 ,  C07C49/593 ,  C07C49/467 ,  C07C49/647 ,  C07C49/697 ,  C07C49/39 ,  C07C231/02 ,  C07C211/40 ,  C07C45/54 ,  C07C209/26 ,  C07D213/803 ,  C07C47/457 ,  C07C233/58 ,  B01J21/02

Abstract: The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d′) further reacting to an enamide, (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.