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    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
    7.
    发明授权
    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions 有权
    呫吨羧酸盐，其制备方法及其作为药物组合物的用途

    公开(公告)号：US07405224B2

    公开(公告)日：2008-07-29

    申请号：US10342080

    申请日：2003-01-14

    申请人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    发明人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    IPC分类号： A61K31/44

    CPC分类号： C07D451/06 ,  C07D451/10

    摘要： Xanthenecarboxylates of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R is hydroxy, methyl, hydroxymethyl, ethyl, —CF3, —CHF2, or fluorine; R1 and R2, which are identical or different, are each C1-C5-alkyl which is optionally substituted by C3-C6-cycloalkyl, hydroxy, or halogen, or R1 and R2 together denote a —C3-C5-alkylene-bridge; and R3, R4, R3′, and R4′, which are identical or different, are each hydrogen, —C1-C4-alkyl, —C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen, or a physiologically acceptable salt thereof, processes for preparing, them and their use in pharmaceutical compositions.

    摘要翻译： 式1的呫吨羧酸盐其中：A是选自X - 的一个基团，是具有单个负电荷的阴离子; R是羟基，甲基，羟甲基，乙基，-CF 3，-CHF 2，或氟; R 1和R 2相同或不同，分别为C 1 -C 5 - 烷基，其中R 1和R 2各自为C 1 -C 5 - 任选被C 3 -C 6 - 环烷基，羟基或卤素取代，或R 1和R 2 - >一起表示-C 3 -C 5 - 亚烷基桥; 和R 3，R 4，R 3，R 3和R 4'相同或不同， 各自为氢，-C 1 -C 4 - 烷基，-C 4 - 烷氧基，羟基，-CF 3 - 或其生理学上可接受的盐，其制备方法，它们及其在药物组合物中的用途。