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公开(公告)号:US4698332A
公开(公告)日:1987-10-06
申请号:US773036
申请日:1985-09-06
IPC分类号: C07H13/08 , A61K31/35 , A61K31/70 , A61K31/7024 , A61P11/10 , C07H11/00 , C07H13/02 , C07H13/04 , C07H13/06
摘要: An expectorant capable of acting on the rheological properties of sputum and capable of directly promoting the ciliary motion. The expectorant contains N-acetylneuraminic acid or a pharmaceutically active salt thereof.
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公开(公告)号:US20060233715A1
公开(公告)日:2006-10-19
申请号:US10545764
申请日:2003-02-21
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K9/14 , A61K9/0043 , A61K38/22 , A61K38/23 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29
摘要: Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
摘要翻译: 提供了包含药物,生理活性肽或肽相关化合物以及作为其载体的具有特定粒径和/或部分预胶化淀粉的结晶纤维素的鼻施用组合物。 这样的组合物改善了药物的体内吸收效率。
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公开(公告)号:US20090169640A1
公开(公告)日:2009-07-02
申请号:US12346537
申请日:2008-12-30
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K9/14 , A61K9/0043 , A61K38/22 , A61K38/23 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29
摘要: Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
摘要翻译: 提供了包含药物,生理活性肽或肽相关化合物以及作为其载体的具有特定粒径和/或部分预胶化淀粉的结晶纤维素的鼻施用组合物。 这样的组合物改善了药物的体内吸收效率。
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公开(公告)号:US07638138B2
公开(公告)日:2009-12-29
申请号:US10545764
申请日:2003-02-21
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K9/14 , A61K9/0043 , A61K38/22 , A61K38/23 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29
摘要: Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
摘要翻译: 提供了包含药物,生理活性肽或肽相关化合物以及作为其载体的具有特定粒径和/或部分预胶化淀粉的结晶纤维素的鼻施用组合物。 这样的组合物改善了药物的体内吸收效率。
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公开(公告)号:US08435554B2
公开(公告)日:2013-05-07
申请号:US12346537
申请日:2008-12-30
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K9/14 , A61K9/0043 , A61K38/22 , A61K38/23 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29
摘要: Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
摘要翻译: 提供了包含药物,生理活性肽或肽相关化合物以及作为其载体的具有特定粒径和/或部分预胶化淀粉的结晶纤维素的鼻施用组合物。 这样的组合物改善了药物的体内吸收效率。
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公开(公告)号:US20050158250A1
公开(公告)日:2005-07-21
申请号:US11078292
申请日:2005-03-14
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K47/38 , A61K9/0043 , A61K9/146 , A61K38/28
摘要: Provided is an insulin-containing granulated composition for nasal administration comprising a crystalline cellulose aggregate having a specific particle diameter distribution as a carrier. Such granulated composition for nasal administration can efficiently increase a blood insulin concentration.
摘要翻译: 本发明提供一种含有胰岛素的用于鼻腔给药的造粒组合物,其包含具有特定粒径分布的结晶纤维素骨料作为载体。 这种用于鼻腔给药的颗粒状组合物可以有效地增加血液中的胰岛素浓度。
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公开(公告)号:US06906027B2
公开(公告)日:2005-06-14
申请号:US10250862
申请日:2002-07-03
申请人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
发明人: Toshikazu Oki , Takashi Hanafusa , Shunji Haruta
CPC分类号: A61K47/38 , A61K9/0043 , A61K9/146 , A61K38/28
摘要: Provided is an insulin-containing granulated composition for nasal administration comprising a crystalline cellulose aggregate having a specific particle diameter distribution as a carrier. Such granulated composition for nasal administration can efficiently increase a blood insulin concentration.
摘要翻译: 本发明提供一种含有胰岛素的用于鼻腔给药的造粒组合物,其包含具有特定粒径分布的结晶纤维素骨料作为载体。 这种用于鼻腔给药的颗粒状组合物可以有效地增加血液中的胰岛素浓度。
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