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1.发明授权Substituted 3,7,9-trioxa-1-aza-2,8-diphosphaspiro(4,5)decanes and stabilized compositions 失效取代3,7,9-三氧杂环己烷-2,3-二氢吡啶并（4,5）癸烷和稳定组合物
公开(公告)号：US5132426A
公开(公告)日：1992-07-21
申请号：US702982
申请日：1991-05-20
IPC分类号： C07F9/6561 , C07F9/6564 , C07F9/6584 , C07F9/6587 , C08K5/5399
CPC分类号： C07F9/65844 , C07F9/6587 , C08K5/5399
摘要： 3,7,9-Trioxa-1-aza-2,8-diphosphaspiro[4.5]decanes of formula I ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl or aryl; or can be halogen when n or m is zero,R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen, alkyl, aralkyl or aryl;X and Y are independently --O--, --S-- or --NR.sub.16 -- where R.sub.16 is alkyl, cycloalkyl, alkenyl, aryl or aralkyl;W and Z are independently O or S; andn, m, o and p are independently zero or 1, are effective in stabilizing organic materials against the deleterious effects of oxygen, heat and/or actinic radiation.
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2.发明授权Process of making 3,7,9-trioxa-1-aza-2,8-diphosphaspiro[4,5]decanes 失效制备3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4,5]癸烷的方法
公开(公告)号：US5239103A
公开(公告)日：1993-08-24
申请号：US975043
申请日：1992-11-12
IPC分类号： C07F9/6584 , C07F9/6587 , C08K5/5399
CPC分类号： C08K5/5399 , C07F9/65844 , C07F9/6587
摘要： 3,7,9-Trioxa-1-aza-2,8-diphosphaspiro[4.5]decanes of formula I ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl or aryl; or can be halogen when n or m is zero,R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen, alkyl, aralkyl or aryl;X and Y are independently --O--, --S-- or --NR.sub.16 -- where R.sub.16 is alkyl, cycloalkyl, alkenyl, aryl or aralkyl;W and Z are independently O or S; andn, m, o and p are independently zero or 1, are effective in stabilizing organic materials against the deleterious effects of oxygen, heat and/or actinic radiation.
摘要翻译： （I）的3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4.5]癸烷其中R 1和R 2独立地是氢，烷基，环烷基，双环烷基，三环烷基或芳基; 或当n或m为零时可以为卤素，R3，R4，R5和R6独立地为氢，烷基，芳烷基或芳基; X和Y独立地是-O - ， - S-或-NR 16 - ，其中R 16是烷基，环烷基，烯基，芳基或芳烷基; W和Z独立地为O或S; 并且n，m，o和p独立地为0或1，有效地稳定有机材料以抵抗氧，热和/或光化辐射的有害影响。
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3.发明授权Substituted 3,7,9-trioxa-1-aza-2,8-diphosphaspiro[4.5]decanes and stabilized compositions 失效取代的3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4.5]癸烷和稳定组合物
公开(公告)号：US5075482A
公开(公告)日：1991-12-24
申请号：US572728
申请日：1990-08-23
IPC分类号： C07F9/6587 , C08K5/5399
CPC分类号： C08K5/5399 , C07F9/6587
摘要： 3,7,9-Trioxa-1-aza-2,8-diphosphaspiro[4.5]decanes of formula I ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl or aryl; or can be halogen when n or m is zero,R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen, alkyl, aralkyl or aryl;X and Y are independently --O-- --S--, or --NR.sub.16 -- where R.sub.16 is alkyl, cycloalkyl, alkenyl, aryl or aralkyl;W and Z are independently O or S; andn, m, o and p are independently zero or 1, are effective in stabilizing organic materials against the deleterious effects of oxygen, heat and/or actinic radiation.
摘要翻译： （I）的3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4.5]癸烷其中R 1和R 2独立地是氢，烷基，环烷基，双环烷基，三环烷基或芳基; 或当n或m为零时可以为卤素，R3，R4，R5和R6独立地为氢，烷基，芳烷基或芳基; X和Y独立地是-O-S-或-NR 16 - ，其中R 16是烷基，环烷基，烯基，芳基或芳烷基; W和Z独立地为O或S; 并且n，m，o和p独立地为0或1，有效地稳定有机材料以抵抗氧，热和/或光化辐射的有害影响。
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">4.发明授权Alpha crystalline modification of 2,2',2"-nitrilo triethyl-tris-(3,3',5,5'-t'-biphenyl-2,2'-diyl) phosphite! 失效2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基） 亚磷酸酯]
公开(公告)号：US5512621A
公开(公告)日：1996-04-30
申请号：US152106
申请日：1993-11-12
申请人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
发明人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
IPC分类号： C09K15/32 , C07F9/6574 , C08K5/49 , C08K5/527 , C07F9/145
CPC分类号： C07F9/65746 , C08K5/527
摘要： The alpha crystalline modification of 2,2',2"-nitrilo triethyl-tris-(3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl)phosphite! is obtained by crystallizing said compound from selected solvents, preferably from a mixture of an aromatic hydrocarbon solvent and a lower alkanol.The alpha crystalline form is an effective process stabilizer for polyolefins, particularly polypropylene.
摘要翻译： 2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基 ）亚磷酸酯]通过从所选溶剂中优选从芳族烃溶剂和低级链烷醇的混合物中结晶所得化合物而获得。 α结晶形式是聚烯烃，特别是聚丙烯的有效工艺稳定剂。
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">5.发明授权Gamma crystalline modification of 2.2',2"-nitrilo[triethyl-tris-(3,3',5,5'-t'-biphenyl-2,2'-diyl) phosphite] 失效2.2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基）亚磷酸酯的γ结晶改性]
公开(公告)号：US5405893A
公开(公告)日：1995-04-11
申请号：US198247
申请日：1994-02-18
申请人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
发明人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
CPC分类号： C08K5/527 , C07F9/65746
摘要： The gamma crystalline modification of 2,2',2"-nitrilo[triethyl-tris-(3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl)phosphite] is obtained by crystallizing or recrystallizing said compound from an alkanol of 4 to 8 carbon atoms.The gamma crystalline form is an effective process stabilizer for polyolefins, particularly polypropylene.
摘要翻译： 2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基 ）亚磷酸酯]是通过使所述化合物从4至8个碳原子的链烷醇中结晶或重结晶获得的。 γ晶型是聚烯烃，特别是聚丙烯的有效工艺稳定剂。
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">6.发明授权Gamma crystalline modification of 2,2', 2"-nitrilo[triethyl-tris(3,3',5,5'-t'-biphenyl-2,2'-diyl) phosphite] 失效2,2 + 40,2“ - 次氮基（三乙基 - 三（3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基） 亚磷酸酯]
公开(公告)号：US5331031A
公开(公告)日：1994-07-19
申请号：US108964
申请日：1993-08-18
申请人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
发明人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
IPC分类号： C07F9/6574 , C08K5/527 , C08K5/52
CPC分类号： C07F9/65746 , C08K5/527
摘要： The gamma crystalline modification of 2,2',2"-nitrilo[triethyl-tris-(3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl)phosphite] is obtained by crystallizing or recrystallizing said compound from an alkanol of 4 to 8 carbon atoms.The gamma crystalline form is an effective process stabilizer for polyolefins, particularly polypropylene.
摘要翻译： 2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基 ）亚磷酸酯]是通过使所述化合物从4至8个碳原子的链烷醇中结晶或重结晶获得的。 γ晶型是聚烯烃，特别是聚丙烯的有效工艺稳定剂。
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7.发明授权Stabilized copositions comprising 3,7,9-trioxa-1-aza-2,8-diphosphaspiro[4,5]decanes 失效包含3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4,5]癸烷的稳定组合物
公开(公告)号：US5187213A
公开(公告)日：1993-02-16
申请号：US843790
申请日：1992-02-27
IPC分类号： C07F9/6584 , C07F9/6587 , C08K5/5399
CPC分类号： C08K5/5399 , C07F9/65844 , C07F9/6587
摘要： 3,7,9-Trioxa-1-aza-2,8-diphosphaspiro[4.5]decanes of formula I ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, alkyl, cycloalkyl, bicycloalkyl, tricycloalkyl or aryl; or can be halogen when n or m is zero,R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently hydrogen, alkyl, aralkyl or aryl;X and Y are independently --O--, --S-- or --NR.sub.16 -- where R.sub.16 is alkyl, cycloalkyl, alkenyl, aryl or aralkyl;W and Z are independently O or S; andn, m, o and p are independently zero or 1, are effective in stabilizing organic materials against the deleterious effects of oxygen, heat and/or actinic radiation.
摘要翻译： （I）的3,7,9-三氧杂-1-氮杂-2,8-二磷杂螺[4.5]癸烷其中R 1和R 2独立地是氢，烷基，环烷基，双环烷基，三环烷基或芳基; 或当n或m为零时可以为卤素，R3，R4，R5和R6独立地为氢，烷基，芳烷基或芳基; X和Y独立地是-O - ， - S-或-NR 16 - ，其中R 16是烷基，环烷基，烯基，芳基或芳烷基; W和Z独立地为O或S; 并且n，m，o和p独立地为0或1，有效地稳定有机材料以抵抗氧，热和/或光化辐射的有害影响。
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8.发明授权
公开(公告)号：US06054614A
公开(公告)日：2000-04-25
申请号：US65272
申请日：1998-04-23
申请人： Sai P. Shum , Paul A. Odorisio , Stephen D. Pastor
发明人： Sai P. Shum , Paul A. Odorisio , Stephen D. Pastor
IPC分类号： A61P25/24 , A61K31/136 , C07B61/00 , C07C249/02 , C07C251/20
CPC分类号： C07C249/02 , C07C2102/10
摘要： 4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene-methylamine and related analogs are prepared from .alpha.-tetralone by a facile three-step process. This compound is the required intermediate to prepare sertraline, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine. Sertraline has selective serotonin uptake inhibitor activity making it a valuable antidepressant pharmaceutical product.
摘要翻译： 4-（3,4-二氯苯基）-3,4-二氢-2H-萘-1-亚基 - 甲胺和相关的类似物由α-四氢萘酮通过简便的三步法制备。 该化合物是制备舍曲林（1S-顺式）-4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺所需的中间体。 舍曲林具有选择性的5-羟色胺摄取抑制剂活性，使其成为有价值的抗抑郁药物产品。
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">9.发明授权Process an alpha monoclinic crystalline modification of 2,2',2"-nitrilo[triethyl-tris-(3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl- 2,2'-diyl)phosphite] 失效处理2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'）的α-单斜晶体改性 - 二基）亚磷酸酯]
公开(公告)号：US5334739A
公开(公告)日：1994-08-02
申请号：US983180
申请日：1992-11-30
申请人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
发明人： Stephen D. Pastor , Sai P. Shum , Paul A. Odorisio
IPC分类号： C09K15/32 , C07F9/6574 , C08K5/49 , C08K5/527
CPC分类号： C07F9/65746 , C08K5/527
摘要： The alpha crystalline modification of 2,2',2"-nitrilo[triethyl-tris-(3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl) O"phosphite] is obtained by crystallizing said compound from selected solvents, preferably from a mixture of an aromatic hydrocarbon solvent and a lower alkanol.The alpha crystalline form is an effective process stabilizer for polyolefins, particularly polypropylene.
摘要翻译： 2,2'，2“ - 次氮基[三乙基 - 三 - （3,3'，5,5'-四叔丁基-1,1'-联苯-2,2'-二基 ）亚磷酸酯]是通过使所述化合物从选择的溶剂中，优选由芳族烃溶剂和低级链烷醇的混合物结晶而获得的。 α结晶形式是聚烯烃，特别是聚丙烯的有效工艺稳定剂。
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10.发明授权Process for preparing 4-(substituted phenyl)-3,4-dihydro-2H-naphthalen-1-ones 失效制备4-（取代苯基）-3,4-二氢-2H-萘-1-酮的方法
公开(公告)号：US6103938A
公开(公告)日：2000-08-15
申请号：US259720
申请日：1999-03-01
申请人： Paul A. Odorisio , Stephen D. Pastor , Sai P. Shum
发明人： Paul A. Odorisio , Stephen D. Pastor , Sai P. Shum
CPC分类号： C07C49/697 , C07C45/511 , C07C45/54 , C07C49/67
摘要： 4-(Substituted phenyl)-3,4-dihydro-2H-naphthalen-1-ones, which are useful as intermediates in the preparation of antidepressant agents, are conveniently prepared by reacting 1-substituted naphthalenes and an aromatic moiety in the presence of an acid catalyst. 4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one, which is useful as an intermediate in the preparation of the antidepressant sertraline, is conveniently prepared by reacting 1-naphthyl acetate and o-dichlorobenzene in the presence of an acid catalyst.
摘要翻译： 可用作制备抗抑郁剂的中间体的4-（取代的苯基）-3,4-二氢-2H-萘-1-酮通过1-取代萘和芳族部分在存在 酸催化剂。 可用作制备抗抑郁药舍曲林的中间体的4-（3,4-二氯苯基）-3,4-二氢-2H-萘-1-酮可方便地通过使1-萘基乙酸酯和邻 - 二氯苯在酸催化剂存在下进行。
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