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1.发明授权3-hydroxypropionic acid-producing recombinant microorganism and method of producing 3-hydroxypropionic acid using the same 有权3-羟基丙酸生产重组微生物及使用其的3-羟基丙酸的制备方法公开(公告)号：US09587255B2
公开(公告)日：2017-03-07
申请号：US14411845
申请日：2013-07-01
Applicant: Samsung Electronics Co., Ltd.
Inventor： Chanmoo Lee , Youngsoo Kim , In Suk Choi
CPC classification number: C12P7/42 , C12N9/0008 , C12N9/88 , C12Y102/01003 , C12Y402/0103 , Y02P20/52
Abstract: Disclosed is a method of producing 3-hydroxypropionic acid comprising the step of culturing recombinant microorganism comprising a nucleic acid sequence encoding Ilyobacter polytropus-derived glycerol dehydratase, and a nucleic acid sequence encoding dehydrogenase, which converts 3-hydroxypropionaldehyde into 3-hydroxypropionic acid, and a recombinant microorganism used therefor. According to the present invention, the production of 3-hydroxypropionic acid remarkably increases and the production amount of 1,3-propanediol (1,3-PDO), which is generated as by-products when producing 3-hydroxypropionic acid, remarkably decreases, compared to known recombinant microorganisms comprising gene expressing Klebsiella pneumonia-derived Vitamin B12-dependent glycerol dehydratase.
Abstract translation: 本发明公开了一种生产3-羟基丙酸的方法，其包括培养包含编码多赖氨酸多糖来源的甘油脱水酶的核酸序列的重组微生物和将3-羟基丙醛转化为3-羟基丙酸的编码脱氢酶的核酸序列的步骤，以及 用于其的重组微生物。 根据本发明，3-羟基丙酸的生产显着增加，当产生3-羟基丙酸时作为副产物产生的1,3-丙二醇（1,3-PDO）的生产量显着降低， 与包含表达来自肺炎克雷伯杆菌的维生素B12依赖性甘油脱水酶的基因的已知重组微生物相比。
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2.发明申请3-HYDROXYPROPIONIC ACID-PRODUCING RECOMBINANT MICROORGANISM AND METHOD OF PRODUCING 3-HYDROXYPROPIONIC ACID USING THE SAME 有权3-羟基丙酸生产重组微生物及使用其制备3-羟基丙酸的方法公开(公告)号：US20150240269A1
公开(公告)日：2015-08-27
申请号：US14411845
申请日：2013-07-01
Applicant: Samsung Electronics Co., Ltd.
Inventor： Chanmoo Lee , Youngsoo Kim , In Suk Choi
CPC classification number: C12P7/42 , C12N9/0008 , C12N9/88 , C12Y102/01003 , C12Y402/0103 , Y02P20/52
Abstract: Disclosed is a method of producing 3-hydroxypropionic acid comprising the step of culturing recombinant microorganism comprising a nucleic acid sequence encoding Ilyobacter polytropus-derived glycerol dehydratase, and a nucleic acid sequence encoding dehydrogenase, which converts 3-hydroxypropionaldehyde into 3-hydroxypropionic acid, and a recombinant microorganism used therefor. According to the present invention, the production of 3-hydroxypropionic acid remarkably increases and the production amount of 1,3-propanediol (1,3-PDO), which is generated as by-products when producing 3-hydroxypropionic acid, remarkably decreases, compared to known recombinant microorganisms comprising gene expressing Klebsiella pneumonia-derived Vitamin B12-dependent glycerol dehydratase.
Abstract translation: 本发明公开了一种生产3-羟基丙酸的方法，其包括培养包含编码多赖氨酸多糖来源的甘油脱水酶的核酸序列的重组微生物和将3-羟基丙醛转化为3-羟基丙酸的编码脱氢酶的核酸序列的步骤，以及 用于其的重组微生物。 根据本发明，3-羟基丙酸的生产显着增加，当产生3-羟基丙酸时作为副产物产生的1,3-丙二醇（1,3-PDO）的生产量显着降低， 与包含表达来自肺炎克雷伯杆菌的维生素B12依赖性甘油脱水酶的基因的已知重组微生物相比。
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