公开(公告)号：US20140141418A1

公开(公告)日：2014-05-22

申请号：US13899223

申请日：2013-05-21

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Dong-hyun PARK ,  Sung-woo HONG ,  Kyung-hee PARK ,  Myo-yong LEE

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6844 ,  C12Q2525/207 ,  C12Q2525/307 ,  C12Q2531/119

Abstract: Provided is a dual-hybridization polynucleotide including a first complementary region that is complementary to the 3′-terminus of a target nucleic and a second complementary region that is complementary to the 5′-terminus of the target nucleic acid, a composition and kit including the polynucleotide, and a method of producing a nucleotide sequence complementary to the target nucleic acid. The first complementary region to be bound at the 3′-terminus of the target nucleic acid can be shortened and the target nucleic acid may be amplified with excellent specificity and/or sensitivity.

Abstract translation: 提供了双杂交多核苷酸，其包含与靶核酸的3'末端互补的第一互补区和与靶核酸的5'末端互补的第2互补区，包含 多核苷酸，以及产生与靶核酸互补的核苷酸序列的方法。 可以缩短在靶核酸的3'-末端结合的第一个互补区，并且以优异的特异性和/或灵敏度扩增靶核酸。

公开(公告)号：US20140178885A1

公开(公告)日：2014-06-26

申请号：US14132964

申请日：2013-12-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyung-hee PARK ,  Ye-ryoung Yong ,  Hyun-ju Kang ,  Ga-hee Kim ,  Dong-hyun Park ,  Myo-yong Lee

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.

Abstract translation: 提供乳腺癌诊断组合物和试剂盒，以及通过使用该组合物或试剂盒诊断乳腺癌或获取乳腺癌诊断信息的方法。 该组合物或试剂盒包括与选自hsa-miR-126，hsa-miR-23a，hsa-miR-24，hsa-miR- 19b，hsa-miR-103，hsa-miR-142-3p，hsa-miR-144，hsa-miR-15a，hsa-miR-185，hsa-miR-93和hsa-miR-30c， 或微小RNA的片段。