公开(公告)号：US20170274081A1

公开(公告)日：2017-09-28

申请号：US15468699

申请日：2017-03-24

申请人： Samsung Life Public Welfare Foundation ,  Research & Business Foundation Sungkyunkwan University

发明人： Oh Young Bang ,  Dong Hee Kim ,  Gyeong Joon Moon ,  Hyeon Ho Kim ,  Doo Sung Lee ,  Young Kyu Seo

IPC分类号： A61K47/34 ,  A61K38/19 ,  C08G18/73 ,  C08G18/32 ,  C08G18/48 ,  C08G18/66 ,  A61K9/00 ,  A61K9/107

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/1075 ,  A61K38/195 ,  B82Y5/00 ,  C08G18/3287 ,  C08G18/329 ,  C08G18/3293 ,  C08G18/3861 ,  C08G18/4825 ,  C08G18/4833 ,  C08G18/6685 ,  C08G18/6688 ,  C08G18/73

摘要： The present invention relates to a composition for topically delivering SDF-1 into the brain, in which the composition comprises a dual ionic pH-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic pH-sensitive copolymer containing SDF-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases.

公开(公告)号：US20190038752A1

公开(公告)日：2019-02-07

申请号：US16057695

申请日：2018-08-07

申请人： SAMSUNG LIFE PUBLIC WELFARE FOUNDATION ,  RESEARCH & BUSINESS FOUNDATION SUNGKYUNWAN UNIVERSITY

发明人： Oh Young Bang ,  Dong Hee Kim ,  Gyeong Joon Moon ,  Hyeon Ho Kim ,  Doo Sung Lee ,  Young Kyu Seo

IPC分类号： A61K47/34 ,  C08G18/73 ,  C08G18/66 ,  C08G18/48 ,  C08G18/32 ,  A61K9/00 ,  A61K38/19 ,  A61K9/107 ,  B82Y5/00

摘要： The present invention relates to a composition for topically delivering SDF-1 into the brain, in which the composition comprises a dual ionic pH-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic pH-sensitive copolymer containing SDF-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases.