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公开(公告)号：US06965034B2
公开(公告)日：2005-11-15
申请号：US10329090
申请日：2002-12-23
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
IPC分类号： A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C59/76 , C07C69/007 , C07C69/738 , C07D277/22 , C07D277/24 , C07D313/00 , C07D413/06 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/18 , C07D303/02
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C59/76 , C07C69/007 , C07C69/738 , C07D277/24 , C07D313/00 , C07D413/06 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , C07F7/1892 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
摘要翻译： 本发明提供用于制备埃坡霉素A和B，脱氧脑苷脂A和B及其类似物的收敛方法，其可用于治疗已发展为多药耐药表型的癌症和癌症。 还提供了可用于制备所述埃坡霉素的中间体。
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公开(公告)号：US06603023B2
公开(公告)日：2003-08-05
申请号：US10062376
申请日：2002-02-01
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
IPC分类号： C07D31300
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C59/76 , C07C69/007 , C07C69/738 , C07D277/24 , C07D313/00 , C07D413/06 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , C07F7/1892 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
摘要翻译： 本发明提供用于制备埃坡霉素A和B，脱氧脑苷脂A和B及其类似物的收敛方法，其可用于治疗已发展为多药耐药表型的癌症和癌症。 还提供了可用于制备所述埃坡霉素的中间体。
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公开(公告)号：US06204388B1
公开(公告)日：2001-03-20
申请号：US09257072
申请日：1999-02-24
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin , Scott Kuduk , Christina Harris , Xiu-Guo Zhang , Joseph R. Bertino
IPC分类号： C07D213127
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C59/76 , C07C69/007 , C07C69/738 , C07D277/24 , C07D313/00 , C07D413/06 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , C07F7/1892 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
摘要翻译： 本发明提供用于制备埃坡霉素A和B，脱氧脑苷脂A和B及其类似物的收敛方法，其可用于治疗已发展为多药耐药表型的癌症和癌症。 还提供了可用于制备所述埃坡霉素的中间体。
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公开(公告)号：US06316630B1
公开(公告)日：2001-11-13
申请号：US09588925
申请日：2000-06-06
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , DongFang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J Sorensen , Aaron Balog , Kenneth A. Savin
IPC分类号： C07D213127
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C59/76 , C07C69/007 , C07C69/738 , C07D277/24 , C07D313/00 , C07D413/06 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , C07F7/1892 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
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