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1.发明申请Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them 审中-公开昂丹司琼的新型晶体形式，其制备方法，药物，含有使用它们治疗恶心的新形式和方法的组合物公开(公告)号：US20050131045A1
公开(公告)日：2005-06-16
申请号：US10952165
申请日：2004-09-29
申请人： Judith Aronhime , Sandor Molnar , Csaba Szabo , Erzsebet Meszaros Sos , Szabolcs Salyi , Tivadar Tamas
发明人： Judith Aronhime , Sandor Molnar , Csaba Szabo , Erzsebet Meszaros Sos , Szabolcs Salyi , Tivadar Tamas
IPC分类号： C07D403/06 , A61K31/4178 , C07D43/02
CPC分类号： C07D403/06
摘要： Ondansetron crystalline Forms A, B, and B1 are useful in the treatment of nausea and vomiting. Some of the novel forms have uniquely high melting points. The novel forms are stable against thermally induced polymorphic transition from 30° C. up to their melting points.
摘要翻译： 昂丹司琼结晶形式A，B和B1可用于治疗恶心和呕吐。 一些新颖的形式具有独特的高熔点。 该新型形式对于30℃至其熔点的热诱导多晶型转变是稳定的。
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![Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one](/abs-image/US/2006/11/09/US20060252942A1/abs.jpg.150x150.jpg)
2.发明申请Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one 审中-公开制备1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑-4-酮的方法公开(公告)号：US20060252942A1
公开(公告)日：2006-11-09
申请号：US11482486
申请日：2006-07-07
IPC分类号： C07D403/02
CPC分类号： C07D403/06 , C07D209/88
摘要： A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.
摘要翻译： 提供了可以通过Mannich反应方便地制备的昂丹司琼结构类似物的转氨制备昂丹司琼的方法。 该方法代表了通过转氨制备昂丹司琼的已知方法的改进，因为它具有快速的速率，选择性和易于与反应混合物分离产物。
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![Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one](/abs-image/US/2006/08/29/US07098345B2/abs.jpg.150x150.jpg)
公开(公告)号：US07098345B2
公开(公告)日：2006-08-29
申请号：US10425450
申请日：2003-04-29
IPC分类号： C07D233/58
CPC分类号： C07D403/06 , C07D209/88
摘要： A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.
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公开(公告)号：US07145017B2
公开(公告)日：2006-12-05
申请号：US10635659
申请日：2003-08-05
IPC分类号： C07D277/20
CPC分类号： C07D417/12
摘要： The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.
摘要翻译： 本发明涉及一种合成氨曲南的方法。 具体来说，该方法需要水解[3S- [3α（Z），4] 3 - [[（2-氨基-4-噻唑基）[（1-叔丁氧基羰基-1-甲基乙氧基）亚氨基]乙酰基]氨基] -4-甲基-2-氧代-1-氮杂环丁烷磺酸（t-Bu阿兹曲南）以形成氨曲南。
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公开(公告)号：US07439252B2
公开(公告)日：2008-10-21
申请号：US11293286
申请日：2005-12-01
IPC分类号： C07D498/18 , A61K31/395 , A61P31/04
CPC分类号： C07D498/18 , A61K9/145 , A61K9/1688 , A61K31/4745 , C07D491/14 , C07H19/01
摘要： The present invention provides novel crystalline forms of ascomycin as well as processes for the preparation thereof and pharmaceutical compositions comprising such crystalline forms of ascomycin.
摘要翻译： 本发明提供新颖的子囊霉素结晶形式，以及其制备方法和包含这种结晶形式的子囊霉素的药物组合物。
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公开(公告)号：US20060155119A1
公开(公告)日：2006-07-13
申请号：US11293286
申请日：2005-12-01
IPC分类号： C07D267/22
CPC分类号： C07D498/18 , A61K9/145 , A61K9/1688 , A61K31/4745 , C07D491/14 , C07H19/01
摘要： The present invention provides novel crystalline forms of ascomycin as well as processes for the preparation thereof and pharmaceutical compositions comprising such crystalline forms of ascomycin.
摘要翻译： 本发明提供新颖的子囊霉素结晶形式，以及其制备方法和包含这种结晶形式的子囊霉素的药物组合物。
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公开(公告)号：US20060154953A1
公开(公告)日：2006-07-13
申请号：US11326724
申请日：2006-01-05
IPC分类号： A61K31/4745
CPC分类号： C07D498/18 , A61K31/4745
摘要： The present invention provides amorphous tacrolimus in a free drug particulate form. Also provided are methods for preparing amorphous tacrolimus, and a tablet containing amorphous tacrolimus.
摘要翻译： 本发明提供游离药物颗粒形式的无定形他克莫司。 还提供了制备无定形他克莫司的方法和含有无定形他克莫司的片剂。
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