-
公开(公告)号：US07145017B2
公开(公告)日：2006-12-05
申请号：US10635659
申请日：2003-08-05
IPC分类号： C07D277/20
CPC分类号： C07D417/12
摘要： The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.
摘要翻译： 本发明涉及一种合成氨曲南的方法。 具体来说，该方法需要水解[3S- [3α（Z），4] 3 - [[（2-氨基-4-噻唑基）[（1-叔丁氧基羰基-1-甲基乙氧基）亚氨基]乙酰基]氨基] -4-甲基-2-氧代-1-氮杂环丁烷磺酸（t-Bu阿兹曲南）以形成氨曲南。
-
2.发明申请Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them 审中-公开昂丹司琼的新型晶体形式，其制备方法，药物，含有使用它们治疗恶心的新形式和方法的组合物公开(公告)号：US20050131045A1
公开(公告)日：2005-06-16
申请号：US10952165
申请日：2004-09-29
申请人： Judith Aronhime , Sandor Molnar , Csaba Szabo , Erzsebet Meszaros Sos , Szabolcs Salyi , Tivadar Tamas
发明人： Judith Aronhime , Sandor Molnar , Csaba Szabo , Erzsebet Meszaros Sos , Szabolcs Salyi , Tivadar Tamas
IPC分类号： C07D403/06 , A61K31/4178 , C07D43/02
CPC分类号： C07D403/06
摘要： Ondansetron crystalline Forms A, B, and B1 are useful in the treatment of nausea and vomiting. Some of the novel forms have uniquely high melting points. The novel forms are stable against thermally induced polymorphic transition from 30° C. up to their melting points.
摘要翻译： 昂丹司琼结晶形式A，B和B1可用于治疗恶心和呕吐。 一些新颖的形式具有独特的高熔点。 该新型形式对于30℃至其熔点的热诱导多晶型转变是稳定的。
-
![Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one](/abs-image/US/2006/11/09/US20060252942A1/abs.jpg.150x150.jpg)
3.发明申请Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one 审中-公开制备1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑-4-酮的方法公开(公告)号：US20060252942A1
公开(公告)日：2006-11-09
申请号：US11482486
申请日：2006-07-07
IPC分类号： C07D403/02
CPC分类号： C07D403/06 , C07D209/88
摘要： A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.
摘要翻译： 提供了可以通过Mannich反应方便地制备的昂丹司琼结构类似物的转氨制备昂丹司琼的方法。 该方法代表了通过转氨制备昂丹司琼的已知方法的改进，因为它具有快速的速率，选择性和易于与反应混合物分离产物。
-
![Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one](/abs-image/US/2006/08/29/US07098345B2/abs.jpg.150x150.jpg)
公开(公告)号：US07098345B2
公开(公告)日：2006-08-29
申请号：US10425450
申请日：2003-04-29
IPC分类号： C07D233/58
CPC分类号： C07D403/06 , C07D209/88
摘要： A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.
-
公开(公告)号：US07452991B2
公开(公告)日：2008-11-18
申请号：US10847123
申请日：2004-05-17
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Ehud Amir
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Ehud Amir
IPC分类号： C07D205/085
CPC分类号： C07D417/12
摘要： The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph. In the process of the invention, a polymorph of Aztreonam is dissolved in an absolute C1-6 alcohol in the presence of a base to form a solution, an acid is added to the solution, and the solution is stirred efficiently.
摘要翻译： 本发明涉及氨曲南的β多晶型物，其含有小于2.5％（重量）的残留溶剂和制备所述多晶型物的方法。 在本发明的方法中，在碱的存在下将氨丁三醇的多晶型物溶解在绝对的C 1-6醇中以形成溶液，向溶液中加入酸，并将溶液 被有效地搅拌。
-
6.发明授权公开(公告)号：US07358093B2
公开(公告)日：2008-04-15
申请号：US11723867
申请日：2007-03-22
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： G01N33/15 , G01N21/94 , C07D205/085
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译： 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
-
公开(公告)号：US20050032775A1
公开(公告)日：2005-02-10
申请号：US10882591
申请日：2004-07-01
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： A61P11/00 , A61P31/04 , C07C229/26 , C07D417/12 , A61K31/397 , C07D205/08
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译： 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
-
公开(公告)号：US07262293B2
公开(公告)日：2007-08-28
申请号：US10882591
申请日：2004-07-01
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： C07D417/12
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译： 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
-
公开(公告)号：US20070167424A1
公开(公告)日：2007-07-19
申请号：US11723867
申请日：2007-03-22
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07D417/12 , C07C229/26 , Y10T436/145555
摘要： The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
-
公开(公告)号：US20050014739A1
公开(公告)日：2005-01-20
申请号：US10847123
申请日：2004-05-17
申请人： Viktor Gyollai , Csaba Szabo , Claude Singer
发明人： Viktor Gyollai , Csaba Szabo , Claude Singer
IPC分类号： C07D417/12 , A61K31/397 , C07D205/08
CPC分类号： C07D417/12
摘要： The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph.
摘要翻译： 本发明涉及氨曲南的β多晶型物，其含有小于2.5％（重量）的残留溶剂和制备所述多晶型物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
109 条记录 (耗时 0.021 秒)
