公开(公告)号：US20240271097A1

公开(公告)日：2024-08-15

申请号：US18568172

申请日：2022-06-08

Applicant: Sanford Burnham Prebys Medical Discovery Institute

Inventor： Alexandre COLAS ,  Maria Azzurra MISSINATO ,  Michael S. YU

IPC: C12N5/077 ,  A61K35/30 ,  A61K35/34 ,  C12N5/0793 ,  C12N15/113

CPC classification number: C12N5/0657 ,  A61K35/30 ,  A61K35/34 ,  C12N5/0619 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/999 ,  C12N2506/1307 ,  C12N2506/28 ,  C12N2510/00

Abstract: This present disclosure provides methods and pharmaceutical compositions for cell reprogramming and a pharmaceutical composition comprising the reprogrammed cells. In certain embodiments, the method of reprogramming a cell comprises reducing the expression of at least one barrier gene selected from the group consisting of ATF7IP, JUNB, ZNF207, Sp7, FOXA1, HEXIM2, SMARCA5, SOX15, CHST2 or NCEH1, or if the barrier gene is ATF7IP or SOX15, then the expression of a second barrier gene is also reduced. In another embodiment, the reprogramming method comprises reducing the expression of at least two barrier genes selected from the group consisting of ATF7IP, JUNB, ZNF207 and Sp7.