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公开(公告)号：US11571485B2
公开(公告)日：2023-02-07
申请号：US16349531
申请日：2017-11-16
发明人： Erkki Ruoslahti , Aman Mann , Pablo Scodeller , Sazid Hussain
IPC分类号： A61K49/14 , C07K7/06 , C07K7/08 , A61K38/00 , A61P25/28 , A61P25/00 , A61P29/00 , C07K16/22 , A61K39/00
摘要： The present invention is based on the seminal discovery of a panel of targeting peptides and antibodies that can recognize AD brains at different stages of the disease, starting from early to advanced stage. The peptide probes described here are unique in the field and can be expected to advance understanding on early neurodegenerative changes associated with AD and improve the therapeutic outcomes by early detection and intervention in AD. Further, the invention provides antibodies that can be used to treat AD.
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公开(公告)号：US20210236584A1
公开(公告)日：2021-08-05
申请号：US16770041
申请日：2018-12-06
摘要： Disclosed are methods and compositions for treating traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Significantly, the peptide alone produces therapeutic effect and so can be used in the absence of any other therapeutic compound.
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公开(公告)号：US20220313841A1
公开(公告)日：2022-10-06
申请号：US17827584
申请日：2022-05-27
摘要： Methods and compositions for treating acute brain injury and acute nervous system injury, which include administering to a subject suffering from an acute brain injury or an acute nervous system injury, a therapeutically effective amount of a composition comprising the amino acid sequence CAQK (SEQ ID NO:4).
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公开(公告)号：US20200368365A1
公开(公告)日：2020-11-26
申请号：US16859893
申请日：2020-04-27
发明人： Erkki Ruoslahti , Aman Mann , Pablo Scodeller , Sazid Hussain
摘要： Compositions are disclosed which include a CAQK peptide linked or conjugated to a cargo composition, where the peptide selectively homes the composition to a site of nervous system injury in a subject.
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公开(公告)号：US11458210B2
公开(公告)日：2022-10-04
申请号：US16859893
申请日：2020-04-27
发明人： Erkki Ruoslahti , Aman Mann , Pablo Scodeller , Sazid Hussain
IPC分类号： C07K5/10 , A61K47/62 , A61P43/00 , A61K47/69 , A61K9/51 , C07K5/103 , A61K47/64 , A61K9/00 , A61K48/00
摘要： Compositions are disclosed which include a CAQK peptide linked or conjugated to a cargo composition, where the peptide selectively homes the composition to a site of nervous system injury in a subject.
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公开(公告)号：US11376303B2
公开(公告)日：2022-07-05
申请号：US16770041
申请日：2018-12-06
摘要： Disclosed are methods and compositions for treating traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Significantly, the peptide alone produces therapeutic effect and so can be used in the absence of any other therapeutic compound.
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公开(公告)号：US20210299283A1
公开(公告)日：2021-09-30
申请号：US16349531
申请日：2017-11-16
发明人： Erkki Ruoslahti , Aman Mann , Pablo Scodeller , Sazid Hussain
摘要： The present invention is based on the seminal discovery of a panel of targeting peptides and antibodies that can recognize AD brains at different stages of the disease, starting from early to advanced stage. The peptide probes described here are unique in the field and can be expected to advance understanding on early neurodegenerative changes associated with AD and improve the therapeutic outcomes by early detection and intervention in AD. Further, the invention provides antibodies that can be used to treat AD.
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公开(公告)号：US10653797B2
公开(公告)日：2020-05-19
申请号：US15756947
申请日：2016-09-02
发明人： Erkki Ruoslahti , Aman Mann , Pablo Scodeller , Sazid Hussain
IPC分类号： A61K47/62 , A61P43/00 , C07K5/10 , A61K47/69 , A61K9/51 , C07K5/103 , A61K47/64 , A61K9/00 , A61K48/00
摘要： Disclosed are methods and compositions for selectively targeting sites of traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Also disclosed are methods and compositions for delivering therapeutic compounds to such sites. CAQK-coated nanoparticles containing silencing oligonucleotides provide an alternative to local delivery of therapeutics, which is invasive and can add complications to the injury.
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