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公开(公告)号：US20110207618A1
公开(公告)日：2011-08-25
申请号：US12712161
申请日：2010-02-24
申请人： Sang Hyun Park , Jae Gyoon Ahn , Eun Ji Shin , Young Mi Yoon
发明人： Sang Hyun Park , Jae Gyoon Ahn , Eun Ji Shin , Young Mi Yoon
摘要： According to an embodiment of the present invention, it is possible to rapidly and accurately predict a class label of a predetermined test sample by extracting a disease-specific gene pair from gene pairs on a microarray data set representing an expression level for each of genes of a genome and for each of a plurality of samples by considering the correlation in a normal class and the correlation in a disease class, selecting a highest specific gene pair with the highest correlation among the extracted disease-specific genes, and predicting the class label of the predetermined test sample by using the selected highest specific gene pair.
摘要翻译： 根据本发明的一个实施方案，可以通过从基因组上的基因对提取疾病特异性基因对来快速准确地预测预定测试样品的分类标签，所述微阵列数据集代表每个基因的表达水平 通过考虑正常类别中的相关性和疾病类别中的相关性，选择在所提取的疾病特异性基因中具有最高相关性的最高特异性基因对，并且预测所述类别标签 通过使用所选择的最高特异性基因对来预定的测试样品。
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公开(公告)号：US20110207612A1
公开(公告)日：2011-08-25
申请号：US12712162
申请日：2010-02-24
申请人： Sang Hyun PARK , Chihyun Park , Jae Gyoon Ahn , Young Mi Yoon
发明人： Sang Hyun PARK , Chihyun Park , Jae Gyoon Ahn , Young Mi Yoon
摘要： A copy number variations detecting apparatus and method according to at least one embodiment of the present invention compare column vectors adjacent to each other on array comparative genomic hybridization data (aCGH data) and compartmentalize the aCGH data into a plurality of segments according to the comparison results, compare row vectors within the segments for each segment and reconfigure the segments into a predetermined number of clusters according to the comparison results, selectively determine the segments as a candidate copy number variation zone corresponding to a distribution form of the clusters for each segment, detect the CNVs within the candidate CNVZ for each sample, and perform merging and pruning on the candidate CNVZ(s) to obtain a final CNVZ(s).
摘要翻译： 根据本发明的至少一个实施方案的拷贝数变异检测装置和方法比较了阵列比较基因组杂交数据（aCGH数据）上彼此相邻的列向量，并根据比较结果将aCGH数据划分成多个片段 比较每个段的段内的行向量，并根据比较结果将段重新配置成预定数量的簇，选择性地将段确定为与每个段的簇的分布形式对应的候选拷贝数变化区，检测 候选CNVZ中的每个样本的CNV，并对候选CNVZ进行合并和修剪以获得最终的CNVZ。
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