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1.发明申请Novel endophytic camptothecin and camptothecinoid producing fungi and process of producing the same 有权新颖的内生喜树碱和喜树碱产生真菌及其生产方法公开(公告)号：US20060134762A1
公开(公告)日：2006-06-22
申请号：US11020075
申请日：2004-12-21
申请人： Satish Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Khajuria , Ajit Saxena , Ghulam Qazi , Michael Spiteller
发明人： Satish Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Khajuria , Ajit Saxena , Ghulam Qazi , Michael Spiteller
CPC分类号： C12P17/188 , C12R1/645
摘要： The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).
摘要翻译： 本发明涉及一种用于生产喜树碱和相关喜树碱的新型微生物来源。 本发明还公开了喜树碱（喜树碱）的喜树碱生产，生长，发酵要求和化学分析的分离，筛选。
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2.发明授权公开(公告)号：US07378268B2
公开(公告)日：2008-05-27
申请号：US11020075
申请日：2004-12-21
申请人： Satish Chander Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Kant Khajuria , Ajit Kumar Saxena , Ghulam Nabi Qazi , Michael Spiteller
发明人： Satish Chander Puri , Vijeshwar Verma , Touseef Amna , Geeta Handa , Vinay Gupta , Neelam Verma , Ravi Kant Khajuria , Ajit Kumar Saxena , Ghulam Nabi Qazi , Michael Spiteller
CPC分类号： C12P17/188 , C12R1/645
摘要： The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).
摘要翻译： 本发明涉及一种用于生产喜树碱和相关喜树碱的新型微生物来源。 本发明还公开了喜树碱（喜树碱）的喜树碱生产，生长，发酵要求和化学分析的分离，筛选。
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3.发明授权公开(公告)号：US06660861B1
公开(公告)日：2003-12-09
申请号：US10401119
申请日：2003-03-27
IPC分类号： C07D49114
CPC分类号： C07D491/22
摘要： The present invention relates to the use of dihalomethanes as reagents for the preparation of Topotecan{4-(S)-10(dimethylamino)-methyl-4-ethyl 4,9 dihydroxyl-H-pyrano[3′4′:6,7]indolizino-[1,2-b]quinoline-3,14(4H,12H)dione} from 10-hydroxycamptothecin. The invention discloses the rationale use of dichloromethane under solid-liquid phase transfer catalysis, which can behave both as solvent and a reactant when it serves as a source for C-1 unit for amino-alkylation of 10-hydroxy-4-(S)camptothecin.
摘要翻译： 本发明涉及二卤代甲烷作为制备拓扑替康{4-（S）-10（二甲基氨基） - 甲基-4-乙基-4,9-二羟基-H-吡喃并[3'4'：6,7 ]吲哚并[1,2-b]喹啉-3,14（4H，12H）二酮}。 本发明公开了在固 - 液相转移催化作用下二氯甲烷的理论应用，当其用作10-羟基-4-（S）氨基烷基化的C-1单元的来源时，其可以作为溶剂和反应物， 喜树碱
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