公开(公告)号：US20060134762A1

公开(公告)日：2006-06-22

申请号：US11020075

申请日：2004-12-21

申请人： Satish Puri ,  Vijeshwar Verma ,  Touseef Amna ,  Geeta Handa ,  Vinay Gupta ,  Neelam Verma ,  Ravi Khajuria ,  Ajit Saxena ,  Ghulam Qazi ,  Michael Spiteller

发明人： Satish Puri ,  Vijeshwar Verma ,  Touseef Amna ,  Geeta Handa ,  Vinay Gupta ,  Neelam Verma ,  Ravi Khajuria ,  Ajit Saxena ,  Ghulam Qazi ,  Michael Spiteller

IPC分类号： C12P17/00 ,  C12N1/14

CPC分类号： C12P17/188 ,  C12R1/645

摘要： The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).

摘要翻译： 本发明涉及一种用于生产喜树碱和相关喜树碱的新型微生物来源。 本发明还公开了喜树碱（喜树碱）的喜树碱生产，生长，发酵要求和化学分析的分离，筛选。

公开(公告)号：US06214849B1

公开(公告)日：2001-04-10

申请号：US09326052

申请日：1999-06-04

申请人： Ajit Saxena ,  Dhananjay Sadashiv Bakhle

发明人： Ajit Saxena ,  Dhananjay Sadashiv Bakhle

IPC分类号： A61P1510

CPC分类号： A61K31/455 ,  Y10S514/906

摘要： The present invention discloses the use of nicorandil in treatment of male impotency and female sexual dysfunction. Nitric ester of N-(2-hydroxyethyl) nicotinamide or nicorandil, as it is better known is known as a drug for treatment of circulatory diseases. It is a pyridine derivative. Several clinical tests performed on male patients suffering from impotency including severe penile erectile dysfunction or female patients suffering from female sexual arousal dysfunction consistently showed excellent results. There was not a single instance of any of side effects or other symptoms of toxicity or deaths due to myocardial infarctions as was the case with other drugs including pyrazolopyrimidones compounds.

摘要翻译： 本发明公开了尼可地尔用于治疗男性阳ency和女性性功能障碍的用途。 已知N-（2-羟乙基）烟酰胺或尼可地尔的硝酸酯被称为用于治疗循环系统疾病的药物。 它是吡啶衍生物。 对男性患有严重阴茎勃起功能障碍的男性患者进行的几项临床测试或女性性唤起功能障碍的女性患者一贯表现出良好的效果。 没有任何副作用或其他由于心肌梗死引起的毒性或死亡症状的一例，其他药物包括吡唑并嘧啶化合物也是如此。

公开(公告)号：US20060280817A1

公开(公告)日：2006-12-14

申请号：US11440790

申请日：2006-05-25

申请人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

发明人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

IPC分类号： A61K36/48

CPC分类号： A61K36/48

摘要： The present invention relates to anticancer activity against hepatocellular carcinoma of an extract and fraction isolated from flowers of Butea monosperma. Particularly, this invention relates to anticancer activity against hepatocellular carcinoma of a composition containing markered flavonoid glycosides such as butrin and isobutrin in the range of 2 to 9% by weight, isolated from the flowers of Butea monosperma by extracting the flowers with polar solvent like ethanol, methanol, aqueous ethanol or water, removing fatty non-polar constituents by triturating the extract with solvents such as ethylene chloride, methylene chloride, chloroform or ethyl acetate, suspending the residue in water, extracting with n-butanol and freeze drying the aqueous part.

摘要翻译： 本发明涉及一种提取物对肝细胞癌的抗癌活性和从白花单倍体花中分离的部分。 特别地，本发明涉及通过用极性溶剂如乙醇提取鲜花，从含有白芍的花中分离出含有2至9重量％的标记的类黄酮苷类的标记黄酮糖苷类化合物的抗癌活性 ，甲醇，乙醇水溶液或水中，通过用溶剂如氯化乙烯，二氯甲烷，氯仿或乙酸乙酯研磨提取物除去脂肪非极性组分，将残余物悬浮在水中，用正丁醇萃取并冷冻干燥含水部分 。