公开(公告)号：US20090263792A1

公开(公告)日：2009-10-22

申请号：US12090644

申请日：2006-10-19

申请人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu ,  Zenro Ikezawa ,  Michiko Aihara ,  Kayano Moriyama

发明人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu ,  Zenro Ikezawa ,  Michiko Aihara ,  Kayano Moriyama

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/6881 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/202

摘要： It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein the specific proteins change their expression with inflammation caused by atopic dermatitis or change their expression according to the degree of predisposition to atopic dermatitis. The present invention also provides a kit for determining the degree of inflammation of atopic dermatitis or risk of developing atopic dermatitis, as well as a method for determining substances effective in the treatment and/or prevention of atopic dermatitis.

摘要翻译： 本发明的目的是找到可用作特应性皮炎的疾病标志物的物质，本发明提供了一种确定特应性皮炎的方法，包括测定皮肤细胞中特异性蛋白质和/或其基因的表达， /或皮肤组织，其中特异性蛋白质根据特应性皮炎引起的炎症改变其表达，或根据对特应性皮炎的倾向程度改变其表达。 本发明还提供了用于确定特应性皮炎炎症程度或发展特应性皮炎风险的试剂盒，以及用于确定有效治疗和/或预防特应性皮炎的物质的方法。

公开(公告)号：US07820396B2

公开(公告)日：2010-10-26

申请号：US12090644

申请日：2006-10-19

申请人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu ,  Zenro Ikezawa ,  Michiko Aihara ,  Kayano Moriyama

发明人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu ,  Zenro Ikezawa ,  Michiko Aihara ,  Kayano Moriyama

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/6881 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/202

摘要： It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein the specific proteins change their expression with inflammation caused by atopic dermatitis or change their expression according to the degree of predisposition to atopic dermatitis. The present invention also provides a kit for determining the degree of inflammation of atopic dermatitis or risk of developing atopic dermatitis, as well as a method for determining substances effective in the treatment and/or prevention of atopic dermatitis.

摘要翻译： 本发明的目的是找到可用作特应性皮炎的疾病标志物的物质，本发明提供了一种确定特应性皮炎的方法，包括测定皮肤细胞中特异性蛋白质和/或其基因的表达， /或皮肤组织，其中特异性蛋白质根据特应性皮炎引起的炎症改变其表达，或根据对特应性皮炎的倾向程度改变其表达。 本发明还提供了用于确定特应性皮炎炎症程度或发展特应性皮炎风险的试剂盒，以及用于确定有效治疗和/或预防特应性皮炎的物质的方法。

公开(公告)号：US07972788B2

公开(公告)日：2011-07-05

申请号：US12064602

申请日：2006-08-22

申请人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu

发明人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A61K38/17 ,  C08H1/06

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/6881

摘要： It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.

摘要翻译： 本发明的目的是找到可用作皮肤老化标记的物质，本发明提供了一种测定皮肤老化程度的方法，包括测定分泌蛋白和/或细胞内蛋白质的表达和/或 它们在皮肤细胞和/或皮肤组织中的基因，其中分泌蛋白和/或细胞内蛋白质随着皮肤老化而改变其表达。 本发明还提供了用于确定皮肤老化程度的试剂盒以及用于鉴定有效预防皮肤老化的物质的方法。

公开(公告)号：US20090305242A1

公开(公告)日：2009-12-10

申请号：US12064602

申请日：2006-08-22

申请人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu

发明人： Satoshi Miyata ,  Kaoru Miyazaki ,  Chie Yasuda ,  Akihiro Iwamatsu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/6881

摘要： It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.

摘要翻译： 本发明的目的是找到可用作皮肤老化标记的物质，本发明提供了一种测定皮肤老化程度的方法，包括测定分泌蛋白和/或细胞内蛋白质的表达和/或 它们在皮肤细胞和/或皮肤组织中的基因，其中分泌蛋白和/或细胞内蛋白质随着皮肤老化而改变其表达。 本发明还提供了用于确定皮肤老化程度的试剂盒以及用于鉴定有效预防皮肤老化的物质的方法。