公开(公告)号：US20120122773A1

公开(公告)日：2012-05-17

申请号：US13380376

申请日：2010-06-24

申请人： Satoshi Suetsugu ,  Nobuhisa Fukuda ,  Yoshio Nakai ,  Takashi Takada ,  Yohei Ikuma ,  Hiroyuki Nakahira

发明人： Satoshi Suetsugu ,  Nobuhisa Fukuda ,  Yoshio Nakai ,  Takashi Takada ,  Yohei Ikuma ,  Hiroyuki Nakahira

IPC分类号： A61K31/538 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5415 ,  A61K31/5386 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/55 ,  A61K31/454 ,  A61K38/28 ,  A61K38/26 ,  A61K38/02 ,  A61K31/549 ,  A61P3/10 ,  A61P3/04 ,  A61P9/12 ,  C07D413/12

CPC分类号： A61K31/4709 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is —N(R1b)—, G2 is —CO—, G3 is —C(R1c)(R1d)—, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

摘要翻译： 本发明提供式（I）化合物：其中R 1a为任选取代的C 1-6烷基等; R1m是氢原子等; G1，G2，G3和G4是（i）等（（i）G1是-N（R1b） - ，G2是-CO-，G3是-C（R1c）（R1d） - ，G4是氧， 等等。）; R 1b是任选取代的C 1-6烷基等; R1c和R1d各自独立地为任选取代的C 1-6烷基等; R2是任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d各自独立地为基团：-A-B（A为单键等，B为氢原子等）等; n为1等; R5是C1-4烷氧基羰基等，或其药学上可接受的盐，其可用作肾素抑制剂。

公开(公告)号：US08658639B2

公开(公告)日：2014-02-25

申请号：US13380376

申请日：2010-06-24

申请人： Satoshi Suetsugu ,  Nobuhisa Fukuda ,  Yoshio Nakai ,  Takashi Takada ,  Yohei Ikuma ,  Hiroyuki Nakahira

发明人： Satoshi Suetsugu ,  Nobuhisa Fukuda ,  Yoshio Nakai ,  Takashi Takada ,  Yohei Ikuma ,  Hiroyuki Nakahira

IPC分类号： A61K31/538 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5415 ,  A61K31/5386 ,  C07D401/12

CPC分类号： A61K31/4709 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is —N(R1b)—, G2 is —CO—, G3 is —C(R1c)(R1d)—, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

摘要翻译： 本发明提供式（I）化合物：其中R 1a为任选取代的C 1-6烷基等; R1m是氢原子等; G1，G2，G3和G4是（i）等（（i）G1是-N（R1b） - ，G2是-CO-，G3是-C（R1c）（R1d） - ，G4是氧， 等等。）; R 1b是任选取代的C 1-6烷基等; R1c和R1d各自独立地为任选取代的C 1-6烷基等; R2是任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d各自独立地为基团：-A-B（A为单键等，B为氢原子等）等; n为1等; R5是C1-4烷氧基羰基等，或其药学上可接受的盐，其可用作肾素抑制剂。

公开(公告)号：US20110190278A1

公开(公告)日：2011-08-04

申请号：US12809489

申请日：2008-12-19

申请人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Kozo Yoshida ,  Hidenori Kimura ,  Satoshi Suetsugu ,  Akira Fusano ,  Kiyoto Sawamura ,  Junya Ikeda ,  Yoshio Nakai

发明人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Kozo Yoshida ,  Hidenori Kimura ,  Satoshi Suetsugu ,  Akira Fusano ,  Kiyoto Sawamura ,  Junya Ikeda ,  Yoshio Nakai

IPC分类号： A61K31/5415 ,  C07D413/12 ,  A61K31/538 ,  C07D413/14 ,  C07D401/12 ,  A61K31/454 ,  A61K31/4709 ,  C07D417/12 ,  A61K31/547 ,  A61P9/12

CPC分类号： C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D498/10

摘要： The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is —N(R1b)—, etc.; G2 is —CO—, etc.; G3 is —C(R1c)(R1d)—, etc.; G4 is oxygen, etc.; R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are independently the same or different, H, etc.; R3 is H, optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

摘要翻译： 本发明涉及用作肾素抑制剂的下式（I）化合物或其药学上可接受的盐。 [其中R1a是卤素等; R1m为H等; G1是-N（R1b） - 等; G2是-CO-等; G3是-C（R1c）（R1d） - 等; G4是氧气等; R 1b是任选取代的C 1-6烷基等; R1c和R1d独立地相同或不同，H等; R3是H，任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d独立地相同或不同，组：-A-B（所述A为单键等，所述B为H等）等; n为1等]

公开(公告)号：US08389511B2

公开(公告)日：2013-03-05

申请号：US12809489

申请日：2008-12-19

申请人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Kozo Yoshida ,  Hidenori Kimura ,  Satoshi Suetsugu ,  Akira Fusano ,  Kiyoto Sawamura ,  Junya Ikeda ,  Yoshio Nakai

发明人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Kozo Yoshida ,  Hidenori Kimura ,  Satoshi Suetsugu ,  Akira Fusano ,  Kiyoto Sawamura ,  Junya Ikeda ,  Yoshio Nakai

IPC分类号： A61K31/5415 ,  A61K31/538 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/547 ,  C07D413/12 ,  C07D413/14 ,  C07D401/12 ,  C07D417/12 ,  A61P9/12

CPC分类号： C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D498/10

摘要： The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is —N(R1b)—, etc.; G2 is —CO—, etc.; G3 is —C(R1c)(R1d)—, etc.; G4 is oxygen, etc.; R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are independently the same or different, H, etc.; R3 is H, optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

摘要翻译： 本发明涉及用作肾素抑制剂的下式（I）化合物或其药学上可接受的盐。 [其中R1a是卤素等; R1m为H等; G1是-N（R1b） - 等; G2是-CO-等; G3是-C（R1c）（R1d） - 等; G4是氧气等; R 1b是任选取代的C 1-6烷基等; R1c和R1d独立地相同或不同，H等; R3是H，任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d独立地相同或不同，组：-A-B（所述A为单键等，所述B为H等）等; n为1等]

公开(公告)号：US20100056497A1

公开(公告)日：2010-03-04

申请号：US12524921

申请日：2008-01-30

申请人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Tomonori Kobayashi ,  Shinya Tosaki

发明人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Tomonori Kobayashi ,  Shinya Tosaki

IPC分类号： A61K31/4462 ,  C07D211/56 ,  C07D207/14 ,  C07D223/12 ,  C07D401/12 ,  C07D413/12 ,  A61P9/12 ,  A61K31/40 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/5377

CPC分类号： C07D207/14 ,  C07D211/56 ,  C07D221/22 ,  C07D223/12

摘要： The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH2)sO—, —(CH2)sN(R4)CO—, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

摘要翻译： 本发明涉及可用作肾素抑制剂的式（I）化合物或其药学上可接受的盐。 其中R 1a是氢原子，任选取代的C 1-6烷基等; R1b是任选取代的C 1-6烷氧基等; R1c是氢原子，任选被取代的C 1-6烷氧基等; R2是氢原子，任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d独立地相同或不同，并且各自为下式基团：其中A为单键， - （CH2）sO-， - （CH2）sN（R4）CO - 等等，B是氢原子，任选取代的C 1-6烷基等）等; R4是氢原子，任意取代的C 1-6烷基等; s为0等 n为1等