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12 条记录 (耗时 0.051 秒)

    AMIDE DERIVATIVE
    5.
    发明申请
    AMIDE DERIVATIVE 审中-公开

    公开(公告)号：US20100056497A1

    公开(公告)日：2010-03-04

    申请号：US12524921

    申请日：2008-01-30

    申请人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Tomonori Kobayashi ,  Shinya Tosaki

    发明人： Hiroyuki Nakahira ,  Yohei Ikuma ,  Nobuhisa Fukuda ,  Tomonori Kobayashi ,  Shinya Tosaki

    IPC分类号： A61K31/4462 ,  C07D211/56 ,  C07D207/14 ,  C07D223/12 ,  C07D401/12 ,  C07D413/12 ,  A61P9/12 ,  A61K31/40 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/5377

    CPC分类号： C07D207/14 ,  C07D211/56 ,  C07D221/22 ,  C07D223/12

    摘要： The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH2)sO—, —(CH2)sN(R4)CO—, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

    摘要翻译： 本发明涉及可用作肾素抑制剂的式（I）化合物或其药学上可接受的盐。 其中R 1a是氢原子，任选取代的C 1-6烷基等; R1b是任选取代的C 1-6烷氧基等; R1c是氢原子，任选被取代的C 1-6烷氧基等; R2是氢原子，任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d独立地相同或不同，并且各自为下式基团：其中A为单键， - （CH2）sO-， - （CH2）sN（R4）CO - 等等，B是氢原子，任选取代的C 1-6烷基等）等; R4是氢原子，任意取代的C 1-6烷基等; s为0等 n为1等

    Pipe joint
    6.
    发明授权
    Pipe joint 失效
    管接头

    公开(公告)号：US5722695A

    公开(公告)日：1998-03-03

    申请号：US699252

    申请日：1996-08-19

    申请人： Shigeyuki Matsumoto ,  Yasuo Yabe ,  Kenji Fuse ,  Yasuyoshi Maruhashi ,  Mitsuaki Motoda ,  Kenji Miyatani ,  Tsuneyoshi Shibata ,  Masao Kanazawa ,  Minoru Sunaga ,  Nobuhisa Fukuda

    发明人： Shigeyuki Matsumoto ,  Yasuo Yabe ,  Kenji Fuse ,  Yasuyoshi Maruhashi ,  Mitsuaki Motoda ,  Kenji Miyatani ,  Tsuneyoshi Shibata ,  Masao Kanazawa ,  Minoru Sunaga ,  Nobuhisa Fukuda

    IPC分类号： F16L21/06 ,  F16L21/08 ,  F16L55/00

    CPC分类号： F16L21/005 ,  F16L17/04 ,  F16L21/08

    摘要： A pipe joint for connecting water supply pipe together and which utilizes compression seals between the pipe and the joint, and is comprised of a holding housing having a band body that surround a seal ring and a holding ring. A locking bolt is threadably tightened onto the holding housing. The seal ring is embedded and sealed within outside surface of both ends of the separated pipes after the locking bolt is threadably tightened. The holding ring is positioned to engage and become fully engaged within the groove at each of outside of the separated pipes, and hold the separation pipes against being easily separated after the locking bolt is threadably tight-end onto the holding housing. The ring spring having a turned up portion eliminate swell out of the holding ring from the holding housing, and circumference rotation by itself. The ring expander creatable enlargement of circumference clearance between adjacent segment of the holding ring allowed the diameter enlargement of the holding ring against compress force of the ring spring. The setting member maintainable diameter enlargement of the holding ring after removal of the ring expander is at ease of prior to installing of the pipe joint for connecting the separated pipes.

    摘要翻译： 一种用于将供水管连接在一起并且在管和接头之间采用压缩密封的管接头，并且包括具有包围密封圈和保持环的带体的保持壳体。 锁紧螺栓螺纹拧紧到保持壳体上。 在螺栓拧紧后，密封圈嵌入并密封在分离管道两端的外表面。 保持环定位成在分离管的每个外侧处于凹槽内接合并完全接合，并且在锁定螺栓螺纹紧固到保持壳体之后，保持分离管不容易分离。 具有翻转部分的环形弹簧消除了保持环从保持壳体的膨胀，并且其自身周长旋转。 环形扩张器在保持环的相邻节段之间的圆周间隙的可增大的形状允许保持环的直径扩大抵抗环形弹簧的压缩力。 除去环形膨胀机之后，固定环的可固定直径的扩大容易地安装用于连接分离的管的管接头。