公开(公告)号：US20040053953A1

公开(公告)日：2004-03-18

申请号：US10390078

申请日：2003-03-17

申请人： Schering Corporation

发明人： Arthur G. Taveras ,  Motasim Billah ,  Daniel Lundell ,  William Kreutner ,  James Jakway ,  Jay S. Fine ,  Loretta A. Bober ,  Jianhua Chao ,  Purakkattle J. Biju ,  Younong Yu

IPC分类号： A61K031/44 ,  A61K031/426 ,  A61K031/421 ,  A61K031/4172 ,  A61K031/34

CPC分类号： A61K45/06

摘要： Methods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula 1 or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine-mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).

摘要翻译： 公开了治疗趋化因子介导的疾病的方法。 所述方法包括与其它类别的药物化合物组合施用下式的CXC趋化因子受体拮抗剂或其药学上可接受的盐或溶剂合物。 趋化因子介导的疾病包括急性和慢性炎性疾病，牛皮癣，囊性纤维化，哮喘和癌症。 还公开了式（I）的新化合物。