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公开(公告)号：US12122823B2
公开(公告)日：2024-10-22
申请号：US17406400
申请日：2021-08-19
申请人： Scholar Rock, Inc.
发明人： Abhishek Datta , Allan Capili , Thomas Schurpf , Constance Martin , Kevin B. Dagbay , Christopher Chapron , Stefan Wawersik , Christopher Littlefield , Gregory J. Carven , Alan Buckler , Susan Lin , Justin W. Jackson , Caitlin Stein , Matthew Salotto , Andrew Avery , Anthony Cooper
IPC分类号： C07K16/22 , A61K39/00 , A61K39/395 , A61K45/06 , A61K49/00 , A61P1/16 , A61P13/12 , A61P35/00 , C07K16/28
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K49/0008 , A61P1/16 , A61P13/12 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/77 , C07K2317/92
摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
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公开(公告)号：US20210340238A1
公开(公告)日：2021-11-04
申请号：US17258908
申请日：2019-07-11
申请人： Scholar Rock, Inc.
发明人： Abhishek Datta , Thomas Schurpf , Allan Capili , Stefan Wawersik , Christopher Chapron , Christopher Littlefield , Gregory J. Carven , Kevin B. Dagbay , Susan Lin , Justin W. Jackson , Caitlin Stein
摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1. Related compositions, methods and therapeutic use are also disclosed.
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公开(公告)号：US20200079840A1
公开(公告)日：2020-03-12
申请号：US16509068
申请日：2019-07-11
申请人： Scholar Rock, Inc.
发明人： Abhishek Datta , Allan Capili , Thomas Schurpf , Constance Martin , Kevin B. Dagbay , Christopher Chapron , Stefan Wawersik , Christopher Littlefield , Gregory J. Carven , Alan Buckler , Susan Lin , Justin W. Jackson
IPC分类号： C07K16/22 , A61P13/12 , A61P1/16 , A61P35/00 , A61K49/00 , A61K45/06 , A61K39/395 , C07K16/28
摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
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公开(公告)号：US11365245B2
公开(公告)日：2022-06-21
申请号：US17530786
申请日：2021-11-19
申请人： Scholar Rock, Inc.
发明人： Thomas Schurpf , Justin W. Jackson , George Coricor , Abhishek Datta , Stefan Wawersik , Christopher Littlefield , Adam Fogel , Caitlin Stein , Julia McCreary , Matthew Salotto , Frederick Streich, Jr.
摘要： Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.
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公开(公告)号：US20210122814A1
公开(公告)日：2021-04-29
申请号：US17258771
申请日：2019-07-11
申请人： Scholar Rock, Inc.
发明人： Abhishek Datta , Allan Capili , Thomas Schurpf , Constance Martin , Kevin B. Dagbay , Christopher Chapron , Stefan Wawersik , Christopher Littlefield , Gregory J. Carven , Alan Buckler , Susan Lin , Justin W. Jackson , Caitlin Stein , Andrew Avery , Anthony Cooper , Matthew Salotto
摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
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公开(公告)号：US11214614B2
公开(公告)日：2022-01-04
申请号：US16997438
申请日：2020-08-19
申请人： Scholar Rock, Inc.
发明人： Thomas Schurpf , Justin W. Jackson , George Coricor , Abhishek Datta , Stefan Wawersik , Christopher Littlefield , Adam Fogel , Caitlin Stein , Julia McCreary , Matthew Salotto , Frederick Streich, Jr.
摘要： Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.
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公开(公告)号：US20210047396A1
公开(公告)日：2021-02-18
申请号：US16997438
申请日：2020-08-19
申请人： Scholar Rock, Inc.
发明人： Thomas Schurpf , Justin W. Jackson , George Coricor , Abhishek Datta , Stefan Wawersik , Christopher Littlefield , Adam Fogel , Caitlin Stein , Julia McCreary , Matthew Salotto , Frederick Streich
摘要： Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.
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公开(公告)号：US20220363741A1
公开(公告)日：2022-11-17
申请号：US17746325
申请日：2022-05-17
申请人： Scholar Rock, Inc.
发明人： Thomas Schurpf , Justin W. Jackson , George Coricor , Abhishek Datta , Stefan Wawersik , Christopher Littlefield , Adam Fogel , Caitlin Stein , Julia McCreary , Matthew Salotto , Frederick Streich, JR.
摘要： Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.
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公开(公告)号：US11130803B2
公开(公告)日：2021-09-28
申请号：US16509068
申请日：2019-07-11
申请人： Scholar Rock, Inc.
发明人： Abhishek Datta , Allan Capili , Thomas Schurpf , Constance Martin , Kevin B. Dagbay , Christopher Chapron , Stefan Wawersik , Christopher Littlefield , Gregory J. Carven , Alan Buckler , Susan Lin , Justin W. Jackson , Caitlin Stein , Matthew Salotto , Andrew Avery , Anthony Cooper
IPC分类号： C07K16/22 , A61P35/00 , C07K16/28 , A61K39/395 , A61K39/00 , A61P13/12 , A61P1/16 , A61K49/00 , A61K45/06
摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
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公开(公告)号：US20200231682A1
公开(公告)日：2020-07-23
申请号：US16634336
申请日：2018-07-27
申请人： Scholar Rock, Inc.
摘要： Disclosed herein are inhibitors, such as antibodies, and antigen binding portions thereof, that selectively bind complexes of LTBP1-TGFβ1 and/or LTBP3-TGFβ1. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ1 activation, and treating subjects suffering from TGFβ1-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ1 inhibitor for a subject in need thereof are also provided.
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