公开(公告)号：US20210122814A1

公开(公告)日：2021-04-29

申请号：US17258771

申请日：2019-07-11

申请人： Scholar Rock, Inc.

发明人： Abhishek Datta ,  Allan Capili ,  Thomas Schurpf ,  Constance Martin ,  Kevin B. Dagbay ,  Christopher Chapron ,  Stefan Wawersik ,  Christopher Littlefield ,  Gregory J. Carven ,  Alan Buckler ,  Susan Lin ,  Justin W. Jackson ,  Caitlin Stein ,  Andrew Avery ,  Anthony Cooper ,  Matthew Salotto

IPC分类号： C07K16/22 ,  A61K45/06 ,  A61P35/00

摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

公开(公告)号：US11130803B2

公开(公告)日：2021-09-28

申请号：US16509068

申请日：2019-07-11

申请人： Scholar Rock, Inc.

发明人： Abhishek Datta ,  Allan Capili ,  Thomas Schurpf ,  Constance Martin ,  Kevin B. Dagbay ,  Christopher Chapron ,  Stefan Wawersik ,  Christopher Littlefield ,  Gregory J. Carven ,  Alan Buckler ,  Susan Lin ,  Justin W. Jackson ,  Caitlin Stein ,  Matthew Salotto ,  Andrew Avery ,  Anthony Cooper

IPC分类号： C07K16/22 ,  A61P35/00 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61P13/12 ,  A61P1/16 ,  A61K49/00 ,  A61K45/06

摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

公开(公告)号：US12122823B2

公开(公告)日：2024-10-22

申请号：US17406400

申请日：2021-08-19

申请人： Scholar Rock, Inc.

发明人： Abhishek Datta ,  Allan Capili ,  Thomas Schurpf ,  Constance Martin ,  Kevin B. Dagbay ,  Christopher Chapron ,  Stefan Wawersik ,  Christopher Littlefield ,  Gregory J. Carven ,  Alan Buckler ,  Susan Lin ,  Justin W. Jackson ,  Caitlin Stein ,  Matthew Salotto ,  Andrew Avery ,  Anthony Cooper

IPC分类号： C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  A61P1/16 ,  A61P13/12 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K49/0008 ,  A61P1/16 ,  A61P13/12 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/77 ,  C07K2317/92

摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

公开(公告)号：US20210340238A1

公开(公告)日：2021-11-04

申请号：US17258908

申请日：2019-07-11

申请人： Scholar Rock, Inc.

发明人： Abhishek Datta ,  Thomas Schurpf ,  Allan Capili ,  Stefan Wawersik ,  Christopher Chapron ,  Christopher Littlefield ,  Gregory J. Carven ,  Kevin B. Dagbay ,  Susan Lin ,  Justin W. Jackson ,  Caitlin Stein

IPC分类号： C07K16/22 ,  A61P13/12

摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1. Related compositions, methods and therapeutic use are also disclosed.

公开(公告)号：US20200079840A1

公开(公告)日：2020-03-12

申请号：US16509068

申请日：2019-07-11

申请人： Scholar Rock, Inc.

发明人： Abhishek Datta ,  Allan Capili ,  Thomas Schurpf ,  Constance Martin ,  Kevin B. Dagbay ,  Christopher Chapron ,  Stefan Wawersik ,  Christopher Littlefield ,  Gregory J. Carven ,  Alan Buckler ,  Susan Lin ,  Justin W. Jackson

IPC分类号： C07K16/22 ,  A61P13/12 ,  A61P1/16 ,  A61P35/00 ,  A61K49/00 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28

摘要： Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.