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1.发明申请Detection of penicillin tolerance in group B streptococcus: single nucleotide polymorphisms in penicillin binding protein 4 有权B组链球菌青霉素耐药检测：青霉素结合蛋白单核苷酸多态性4公开(公告)号：US20100028884A1
公开(公告)日：2010-02-04
申请号：US12454408
申请日：2009-05-18
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Disclosed are methods of detecting penicillin tolerance in Group B Streptococcus by detecting at least one of two single nucleotide polymorphisms (SNP) in penicillin binding protein 4. Also disclosed are primers and hybridization probes that may be used in such methods.
摘要翻译： 公开了通过检测青霉素结合蛋白4中的两个单核苷酸多态性（SNP）中的至少一个来检测B组链球菌中的青霉素耐药性的方法。还公开了可用于这些方法的引物和杂交探针。
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2.发明授权公开(公告)号：US08247170B2
公开(公告)日：2012-08-21
申请号：US12454408
申请日：2009-05-18
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Disclosed are methods of detecting penicillin tolerance in Group B Streptococcus by detecting at least one of two single nucleotide polymorphisms (SNP) in penicillin binding protein 4. Also disclosed are primers and hybridization probes that may be used in such methods.
摘要翻译： 公开了通过检测青霉素结合蛋白4中的两个单核苷酸多态性（SNP）中的至少一个来检测B组链球菌中的青霉素耐药性的方法。还公开了可用于这些方法的引物和杂交探针。
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3.发明申请公开(公告)号：US20170314065A1
公开(公告)日：2017-11-02
申请号：US15649969
申请日：2017-07-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is based on the discovery of novel polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.
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4.发明授权公开(公告)号：US09738938B2
公开(公告)日：2017-08-22
申请号：US13068331
申请日：2011-05-09
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is based on the discovery of polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.
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5.发明申请Novel single nucleotide polymorphisms and community-associated methicillin-resistant staphylococcus aureus 有权新型单核苷酸多态性和社区相关耐甲氧西林金黄色葡萄球菌公开(公告)号：US20120009572A1
公开(公告)日：2012-01-12
申请号：US13068331
申请日：2011-05-09
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： The present invention is based on the discovery of novel polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.
摘要翻译： 本发明基于在金黄色葡萄球菌中青霉素结合蛋白（pbp3）基因中新型多态性（SNP）的发现。 G88A和/或G2047A SNP的存在为耐甲氧西林金黄色葡萄球菌（MRSA），特别是社区相关MRSA（CA-MRSA）的存在提供了准确，可靠的生物标志物。 本发明提供用于检测SNP的试剂以及鉴定和使用这些变体筛选受试者存在CA-MRSA的方法。 所述方法包括从哺乳动物（优选人）分离生物样品并测试与CA-MRSA相关的pbp3基因中SNP的存在。
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6.发明授权公开(公告)号：US10221462B2
公开(公告)日：2019-03-05
申请号：US15649969
申请日：2017-07-14
IPC分类号： C12Q1/689
摘要： The present invention is based on the discovery of polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.
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