公开(公告)号：US20210047682A1

公开(公告)日：2021-02-18

申请号：US16591232

申请日：2019-10-02

Applicant: Seagate Technology LLC

Inventor： Gemma MENDONSA ,  Riyan A. MENDONSA ,  Krishnan SUBRAMANIAN

IPC: C12Q1/6869 ,  G01N33/487 ,  G01N27/72

Abstract: Method of utilizing a nanochannel in combination with at least one magnetic sensor for detecting (e.g., identifying) molecules, cells, and other analytes. Particularly, the method includes bringing molecules, labeled with magnetic nanoparticles (MNPs), in close proximity to the magnetic sensor to identify the molecules via an output signal from the magnetic sensor. The method is particularly suited for identifying nucleotides of DNA and RNA strands.

公开(公告)号：US20210047681A1

公开(公告)日：2021-02-18

申请号：US16591162

申请日：2019-10-02

Applicant: Seagate Technology LLC

Inventor： Gemma MENDONSA ,  Riyan A. MENDONSA ,  Krishnan SUBRAMANIAN

IPC: C12Q1/6869 ,  C12Q1/6876

Abstract: Methods of DNA sequencing from a template strand via DNA polymerase immobilized on a magnetic sensor. The methods include forming a complementary strand by the DNA polymerase from individual magnetic nanoparticle (MNP)-labeled nucleotides, and obtaining a signal from the magnetic sensor to identify the MNP and thus the nucleotide. The process can be repeated until the entire complementary strand is formed and identified.