公开(公告)号：US20210011021A1

公开(公告)日：2021-01-14

申请号：US16791174

申请日：2020-02-14

申请人： Seattle Genetics, Inc.

发明人： Ana Paula Galvao da Silva ,  Darius Ghaderi ,  Mai Zhang ,  Kristan Meetze ,  Julie DeSander ,  Jeffrey Behrens ,  David A. Eavarone ,  Jillian M. Prendergast

IPC分类号： G01N33/574 ,  C07K16/30 ,  C07K16/44 ,  A61K47/68 ,  C07K16/00

摘要： The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.

公开(公告)号：US20200276306A1

公开(公告)日：2020-09-03

申请号：US16742434

申请日：2020-01-14

申请人： Seattle Genetics, Inc.

发明人： Ana Paula Galvao da Silva ,  Julie DeSander ,  Jeffrey Behrens ,  Darius Ghaderi ,  Mai Zhang ,  Kristan Meetze

IPC分类号： A61K39/395 ,  C07K16/30 ,  C07K16/44

摘要： The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include mono clonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. In some embodiments, the present invention provides an antibody having a heavy chain with an amino acid sequence comprising at least 95% sequence identity to SEQ ID NO: 63 and having a light chain with an amino acid sequence comprising at least 95% sequence identity to SEQ ID NO: 64.

公开(公告)号：US20210017213A1

公开(公告)日：2021-01-21

申请号：US16850353

申请日：2020-04-16

申请人： Seattle Genetics, Inc.

发明人： Ana Paula Galvao da Silva ,  Mai Zhang ,  Darius Ghaderi ,  Julie DeSander ,  Jeffrey Behrens ,  Jillian M. Prendergast

IPC分类号： C07H15/04 ,  G01N33/574 ,  G01N33/68 ,  C40B40/12

摘要： The invention provides methods and tools, for example, glycan arrays, for the analysis of glycans and anti-glycan antibodies. Embodiments of the invention may be used to detect proteins, antibodies, diseases and/or pathogenic agents. In other embodiments, methods of the invention are used to develop or optimize arrays and antibodies.