Torque limiting mechanism for two rotary members
    1.
    发明授权
    Torque limiting mechanism for two rotary members 失效
    两个旋转构件的扭矩限制机构

    公开(公告)号:US5620372A

    公开(公告)日:1997-04-15

    申请号:US521048

    申请日:1995-08-29

    IPC分类号: F16D7/02 F16H35/10

    CPC分类号: F16D7/022

    摘要: A torque limiter having an inner cylinder, an outer cylinder rotatably mounted around the inner cylinder, a closure member mounted between the outer cylinder and the inner cylinder to close one end of the outer cylinder, a coil spring mounted between the inner cylinder and the outer cylinder and having one end coupled to the outer cylinder and the other end coupled to the closure member so as to be tightened against the outer peripheral surface of the inner cylinder. The outer peripheral surface of the inner cylinder has a roughness Ra (arithmetical mean deviation) of 0.6-1.0, and the coil spring is formed of a wire having a circular cross-section.

    摘要翻译: 具有内筒,可旋转地安装在内筒周围的外筒的扭矩限制器,安装在外筒和内筒之间的封闭构件,以封闭外筒的一端;安装在内筒和外筒之间的螺旋弹簧 并且其一端联接到外筒,另一端联接到封闭构件,以便紧靠在内筒的外周表面上。 内筒的外周面的粗糙度Ra(算术平均偏差)为0.6〜1.0,螺旋弹簧由具有圆形横截面的线形成。

    Mutant proteins of human DNA topoisomerase I
    2.
    发明授权
    Mutant proteins of human DNA topoisomerase I 失效
    人类DNA拓扑异构酶I的突变蛋白

    公开(公告)号:US5849503A

    公开(公告)日:1998-12-15

    申请号:US663112

    申请日:1996-11-26

    IPC分类号: C12N9/90 C12N15/55 G01N33/53

    CPC分类号: C12N9/90

    摘要: Mutant proteins of human DNA topoisomerase I having an amino acid sequence in which tyrosine at the 592nd position of human DNA topoisomerase I is lacking or replaced with phenylalanine and which contains at least 30 amino acids in succession of the amino acid sequence subsequent to the 542nd amino acid of human DNA topoisomerase I. Above described mutant proteins react with anti-Scl-70, antibody in the sera of autoimmune disease patients of diffuse scleroderma and can be produced by genetic engineering using E. coli, and therefore they are useful as a diagnostic agent of scleroderma.

    摘要翻译: PCT No.PCT / JP94 / 02280 Sec。 371日期1996年11月26日 102(e)日期1996年11月26日PCT 1994年12月28日PCT公布。 出版物WO95 / 18218 日期1995年7月6日具有氨基酸序列的人类DNA拓扑异构酶I的突变蛋白I,其中人DNA拓扑异构酶I的第592位的酪氨酸缺乏或被苯丙氨酸替代,并且其氨基酸序列连续包含至少30个氨基酸 在人类DNA拓扑异构酶I的第542位氨基酸之后。上述突变蛋白质与抗Sc1-70抗体在自身免疫性疾病患者的弥漫性硬皮病血清中反应,并且可以通过使用大肠杆菌的遗传工程产生,因此它们 作为硬皮病的诊断剂是有用的。