专利检索 ap:("Senthilkumar Udayampalayam Palanisamy" OR "Maneesh Paul-Satyaseela" OR "Shridhar Narayanan" OR "Gopalan Balasubramanian" OR "Aravind Appu" OR "Senthilnathan Manickam" OR "Hariharan Periasamy") AND inv:"Hariharan Periasamy" 第 1 页

1.

发明授权
Compounds and their use 有权

公开(公告)号：US10201532B2

公开(公告)日：2019-02-12

申请号：US13989600

申请日：2011-11-25

申请人： Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharan Periasamy

发明人： Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharan Periasamy

IPC分类号： A61K31/431 , C07D499/883 , A61K31/397 , A61K31/4025 , A61K31/496 , A61K31/542 , C07D499/00 , C12Q1/44

摘要： Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as β-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of β-lactamases. These compounds restore/potentiate the activities of β-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting β-lactamases.Formula (I)