公开(公告)号：US20030109540A1

公开(公告)日：2003-06-12

申请号：US10269871

申请日：2002-10-15

Applicant: Sepracor Inc.

Inventor： Dean A. Handley ,  Paul D. Rubin

IPC: A61K031/473

CPC classification number: A61K45/06 ,  A61K31/445 ,  A61K31/4545 ,  Y10S514/826 ,  Y10S514/864

Abstract: Methods utilizing descarboethoxyloratadine (nullDCLnull) for the treatment of allergic disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. Also included are methods for the treatment of allergic asthma using DCL and either a decongestant or a leukotriene inhibitor, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. The invention also encompasses the administration of DCL in a nasal or oral spray.

Abstract translation: 利用去甲氧基吡咯烷（“DCL”）治疗过敏性疾病的方法，同时避免与其他非镇静抗组胺药相关的副作用的伴随责任。 还包括使用DCL和减充血剂或白三烯抑制剂治疗过敏性哮喘的方法，同时避免与其它非镇静性抗组胺药相关的副作用的伴随的责任。 本发明还包括以鼻腔或口腔喷雾剂施用DCL。

公开(公告)号：US20020151543A1

公开(公告)日：2002-10-17

申请号：US10158886

申请日：2002-06-03

Applicant: Sepracor Inc.

Inventor： Timothy J. Barberich ,  Paul D. Rubin ,  Dean A. Handley

IPC: A61K031/5513 ,  A61K031/137

CPC classification number: A61K31/495 ,  A61K31/445 ,  A61K31/505 ,  A61K31/55 ,  A61K2300/00

Abstract: Pharmaceutical compositions which comprises R(null) fluoxetine and one or more other biologically active compounds are disclosed. Methods of treating or preventing a disease or disorder, especially a psychotic or psychiatric disease or disorder, using the above pharmaceutical composition or by administering a R(null) fluoxetine in combination with one or more other biologically active compounds are also disclosed. Methods of treating patients having or at risk of having AIDS or HIV infection, cancer, cardiac disorder, post-myocardial depression and posttraumatic stress disorder using optically pure R(null) fluoxetine in combination with one or more other biologically active compounds are further disclosed.

Abstract translation: 公开了包含R（ - ）氟西汀和一种或多种其它生物活性化合物的药物组合物。 还公开了使用上述药物组合物或通过与一种或多种其它生物活性化合物组合施用R（ - ）氟西汀来治疗或预防疾病或障碍，特别是精神病或精神疾病或病症的方法。 进一步公开了使用光学纯的R（ - ）氟西汀与一种或多种其它生物活性化合物组合治疗患有AIDS或HIV感染或有风险患有癌症，心脏病，心肌后抑郁症和创伤后应激障碍的患者的方法。