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    USE OF CREATINE OR CREATINE COMPOUNDS FOR SKIN PRESERVATION
    4.
    发明申请
    USE OF CREATINE OR CREATINE COMPOUNDS FOR SKIN PRESERVATION 审中-公开

    公开(公告)号：US20110021632A1

    公开(公告)日：2011-01-27

    申请号：US12711298

    申请日：2010-02-24

    申请人： Rima KADDURAH-DAOUK

    发明人： Rima KADDURAH-DAOUK

    IPC分类号： A61K31/205 ,  A61P17/02

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K8/55 ,  A61K31/155 ,  A61K31/195 ,  A61K31/198 ,  A61K2800/92 ,  A61Q19/02 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/864

    摘要： The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

    Compositions for the treatment and prevention of cancer
    6.
    发明申请
    Compositions for the treatment and prevention of cancer 审中-公开
    用于治疗和预防癌症的组合物

    公开(公告)号：US20080170997A1

    公开(公告)日：2008-07-17

    申请号：US12077439

    申请日：2008-03-18

    申请人： Gerhard N. Schrauzer

    发明人： Gerhard N. Schrauzer

    IPC分类号： A61K9/12 ,  A61K31/095 ,  A61P35/00

    CPC分类号： A61K47/10 ,  A61K9/0014 ,  A61K9/0031 ,  A61K31/095 ,  A61K47/06 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44 ,  Y10S514/858 ,  Y10S514/859 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/862 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/887

    摘要： Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating organic selenium compounds in combination with inert carriers in therapeutically effective amounts of selenium compound. The selenium compounds are medium linear chain dialkyl diselenides and precursors such as alkyl selenols. Preferred compositions employ R—Se—Se—R compounds where R is from 6 to 8 carbon atoms, and most specifically di-n-hexyl diselenide. Commonly used carriers may be purified hydrocarbon fractions, oils, with or without added fat-soluble vitamins, water and emulsifying agents.

    摘要翻译： 提供组合物用于局部治疗由治疗有效量的硒化合物组成的乳液，霜剂，喷雾剂，栓剂或缓释透皮贴剂，其含有脂溶性，皮肤渗透性有机硒化合物与惰性载体的组合。 硒化合物是中等直链二烷基二硒化物和前体，例如烷基硒。 优选的组合物使用其中R为6至8个碳原子的R-Se-Se-R化合物，最特别的是二正己基二硒化物。 通常使用的载体可以是纯化的烃馏分，油，具有或不具有添加的脂溶性维生素，水和乳化剂。