公开(公告)号：US4321381A

公开(公告)日：1982-03-23

申请号：US188620

申请日：1980-09-19

申请人： Sergio Mantegani ,  Guiliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

发明人： Sergio Mantegani ,  Guiliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

IPC分类号： C07D457/04 ,  A61K31/48 ,  A61P9/12 ,  C07D457/02 ,  A61K31/495

CPC分类号： C07D457/02

摘要： Compounds and process for making same are disclosed, the compounds having the formula (I): ##STR1## wherein R.sub.1 represents methyl, phenyl, piperidino, 1-pyrrolidinyl, morpholino or 4-methyl-1-piperazinyl, alkyl or alkoxy having from 1 to 4 carbon atoms, amino, substituted amino of the formula NHR' (wherein R' is alkyl having from 1 to 4 carbon atoms, cycloalkyl, a benzyl, or phenyl) or substituted amino of the formula NR" R"' (wherein R" and R"' both represent alkyl having from 1 to 4 carbon atoms);R.sub.2 represents a hydrogen atom, alkyl having from 1 to 4 carbon atoms, or phenyl;R.sub.3 represents a fluorine atom, cyano, difluoromethyl, difluorobromomethyl, trifluoromethyl, methylthio, methylsulphonyl, sulphonamido, an alkoxy having from 1 to 4 carbon atoms, an alkanoyl having from 2 to 5 carbon atoms, or benzoyl;R.sub.4 represents a hydrocarbon having from 1 to 4 carbon atoms;R.sub.5 represents a hydrogen atom or methoxy;R.sub.6 represents a hydrogen or halogen atom or methyl; andR.sub.7 represents a hydrogen atom or methyl. The 2-cyano derivatives are especially preferred.The compounds are useful as antihypertensive agents.