公开(公告)号：US20100249643A1

公开(公告)日：2010-09-30

申请号：US12653114

申请日：2009-12-08

申请人： Shai N. Gozani ,  Ann Pavlik Meyer ,  Xuan Kong ,  Martin D. Wells

发明人： Shai N. Gozani ,  Ann Pavlik Meyer ,  Xuan Kong ,  Martin D. Wells

IPC分类号： A61B5/05

CPC分类号： A61B5/0488 ,  A61B5/0492 ,  A61B5/05 ,  A61B5/1106 ,  A61B5/4041 ,  A61B5/6824 ,  A61B5/6829 ,  A61B5/742 ,  A61B2560/0412 ,  A61B2562/063

摘要： An apparatus and method for detecting physiological function, for example, nerve conduction, is described. In one embodiment the apparatus includes a housing including a stimulator shaped to fit a first anatomical site and a detector shaped to fit a second anatomical site. The housing automatically positions the detector substantially adjacent to the second anatomical site when the stimulator is positioned substantially adjacent to the first anatomical site. The detector contains a plurality of individual detection elements, whereby the response evoked by stimulation at the first anatomical site is measured using one or more of these detection elements at the second anatomical location.

摘要翻译： 描述了用于检测生理功能的装置和方法，例如神经传导。 在一个实施例中，该装置包括壳体，其包括成形为适合第一解剖部位的刺激器和形状适合于第二解剖部位的检测器。 当刺激器基本上与第一解剖部位相邻时，壳体将检测器基本上邻近于第二解剖部位定位。 检测器包含多个单独的检测元件，由此在第二解剖位置使用这些检测元件中的一个或多个来测量在第一解剖部位的刺激引起的反应。

公开(公告)号：US07628761B2

公开(公告)日：2009-12-08

申请号：US10075217

申请日：2002-02-14

申请人： Shai N. Gozani ,  Ann Pavlik Meyer ,  Xuan Kong ,  Martin D. Wells

发明人： Shai N. Gozani ,  Ann Pavlik Meyer ,  Xuan Kong ,  Martin D. Wells

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/04

CPC分类号： A61B5/0488 ,  A61B5/0492 ,  A61B5/05 ,  A61B5/1106 ,  A61B5/4041 ,  A61B5/6824 ,  A61B5/6829 ,  A61B5/742 ,  A61B2560/0412 ,  A61B2562/063

摘要： An apparatus and method for detecting physiological function, for example, nerve conduction, is described. In one embodiment the apparatus includes a housing including a stimulator shaped to fit a first anatomical site and a detector shaped to fit a second anatomical site. The housing automatically positions the detector substantially adjacent to the second anatomical site when the stimulator is positioned substantially adjacent to the first anatomical site. The detector contains a plurality of individual detection elements, whereby the response evoked by stimulation at the first anatomical site is measured using one or more of these detection elements at the second anatomical location.

公开(公告)号：US08326410B2

公开(公告)日：2012-12-04

申请号：US11265027

申请日：2005-11-02

申请人： Xuan Kong ,  Pansy Bansal ,  Shai N. Gozani

发明人： Xuan Kong ,  Pansy Bansal ,  Shai N. Gozani

IPC分类号： A61B5/05

CPC分类号： A61B5/0488 ,  A61B5/04001 ,  A61B5/4041

摘要： A novel submaximal F-wave acquisition and analysis system that employs computational intelligence to set up submaximal F-wave acquisition conditions and to extract submaximal F-wave features automatically, without operator intervention.

摘要翻译： 一种新颖的次最大F波采集和分析系统，采用计算智能建立次最大F波采集条件，并自动提取次最大F波特征，无需操作员干预。

公开(公告)号：US07452335B2

公开(公告)日：2008-11-18

申请号：US10288852

申请日：2002-11-06

申请人： Martin D. Wells ,  Shai N. Gozani

发明人： Martin D. Wells ,  Shai N. Gozani

IPC分类号： A61B5/05 ,  A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/4041

摘要： A method and apparatus for assessing neuromuscular pathology in an individual, by (a) applying a plurality of stimuli to a peripheral nerve; (b) recording from the peripheral nerve, or from a muscle innervated by the peripheral nerve, at least one response to each stimulus; (c) processing each response into at least one response characteristic; (d) compiling the response characteristics from all of the responses into a plurality of descriptive parameters of the response characteristics; and (e) analyzing the plurality of descriptive parameters according to a function specific to the neuromuscular pathology so as to yield an indicator of the pathology.

摘要翻译： 一种用于评估个体神经肌肉病理学的方法和装置，通过（a）将多种刺激应用于周围神经; （b）从周围神经或由周围神经支配的肌肉记录至少一种对每种刺激的反应; （c）将每个响应处理成至少一个响应特征; （d）将来自所有响应的响应特征编译成响应特性的多个描述参数; 和（e）根据对神经肌肉病理学特有的功能分析多个描述参数，以产生病理学的指标。

公开(公告)号：US09173580B2

公开(公告)日：2015-11-03

申请号：US12074346

申请日：2008-03-03

申请人： Xuan Kong ,  Zhixiu Han ,  Shai N. Gozani

发明人： Xuan Kong ,  Zhixiu Han ,  Shai N. Gozani

IPC分类号： A61B5/04 ,  A61B5/0488 ,  A61B5/00

CPC分类号： A61B5/04001 ,  A61B5/0488 ,  A61B5/7239

摘要： A method and apparatus for the assessment of neuromuscular function by estimating motor unit F-wave component time of arrival (TOA), comprising: (i) determining and comparing F-wave component features so as to accurately identify individual F-wave components; (ii) repeatedly searching the individual F-wave components and extracting individual F-wavelets from the F-wave components so as to build a complete F-wave TOA profile; and (iii) computing and reporting TOA results for the assessment of neuromuscular function.

摘要翻译： 一种用于通过估计运动单元F波分量到达时间（TOA）来评估神经肌肉功能的方法和装置，包括：（i）确定和比较F波分量特征，以便准确地识别各个F波分量; （ii）重复搜索单个F波分量并从F波分量中提取单个F小波，以构建完整的F波TOA谱; 和（iii）计算和报告TOA评估神经肌肉功能的结果。

公开(公告)号：US20110071421A1

公开(公告)日：2011-03-24

申请号：US12803785

申请日：2010-07-06

申请人： Shai N. Gozani ,  Xuan Kong

发明人： Shai N. Gozani ,  Xuan Kong

IPC分类号： A61B5/04

CPC分类号： A61B5/04001

摘要： In one form of the present invention, there is provided a method for detecting an A-wave, the method comprising: applying a series of stimuli to a nerve; recording a series of late responses; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics. In another form of the present invention, there is provided a system for detecting an A-wave comprising: a stimulation electrode; a stimulation circuit connected to the stimulation electrode for applying a series of stimuli to a nerve; a detection electrode; a detection circuit connected to the detection electrode; and an analyzer connected to the detection electrode and adapted to detect an A-wave by: recording a series of late responses detected by the detection circuit; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space map that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics.

摘要翻译： 在本发明的一种形式中，提供了一种用于检测A波的方法，所述方法包括：将一系列刺激施加于神经; 录制一系列迟来的回应; 从晚期响应的集合中创建特征空间图; 识别表征A波分量的特征空间内的簇; 将A波分量合并成A波的离散集合; 去除假阳性A波; 并提取A波特性。 在本发明的另一形式中，提供了一种用于检测A波的系统，包括：刺激电极; 连接到刺激电极的刺激电路，用于将一系列刺激施加到神经上; 检测电极; 连接到检测电极的检测电路; 以及连接到所述检测电极并且适于通过以下步骤检测A波的分析器：记录由所述检测电路检测到的一系列后期响应; 从晚期响应的集合中创建特征空间图; 识别表征A波分量的特征空间图内的簇; 将A波分量合并成A波的离散集合; 去除假阳性A波; 并提取A波特性。

公开(公告)号：US07848797B2

公开(公告)日：2010-12-07

申请号：US11893737

申请日：2007-08-17

申请人： Xuan Kong ,  Zhixiu Han ,  Shai N. Gozani

发明人： Xuan Kong ,  Zhixiu Han ,  Shai N. Gozani

IPC分类号： A61B5/04 ,  A61B5/05

CPC分类号： A61B5/04001 ,  A61B5/05 ,  A61B5/1106 ,  A61B5/4041 ,  A61B5/4519 ,  A61B5/6825

摘要： A method for the assessment of neuromuscular function by motor unit number estimation, comprising: (i) determining and controlling stimulation and data acquisition process via pre-configured electrode array so as to acquire stable and less uncertainty MU responses; (ii) pre-processing acquired MUs responses so as to attenuate noise, determine MUs activity region, and improve processing speed and accuracy; (iii) minimizing alternation effects by globally searching and comparing SMUPs; (iv) eliminating alternation effects by identifying alternating MUs directly; and (v) computing and reporting MUNE results, as well as the statistical description of these MUN estimates to evaluate its robustness.

摘要翻译： 一种用于通过运动单元数量估计来评估神经肌肉功能的方法，包括：（i）通过预配置的电极阵列确定和控制刺激和数据采集过程，以获得稳定且较小的不确定性MU响应; （ii）预处理获得的MU响应，以减弱噪声，确定MU活动区域，并提高处理速度和准确性; （iii）通过全球搜索和比较SMUP来最小化交替效应; （iv）通过直接识别交替的疏忽来消除交替效应; 和（v）计算和报告MUNE结果，以及这些MUN估计的统计描述以评估其鲁棒性。

公开(公告)号：US07749171B2

公开(公告)日：2010-07-06

申请号：US11076789

申请日：2005-03-09

申请人： Shai N. Gozani ,  Xuan Kong

发明人： Shai N. Gozani ,  Xuan Kong

IPC分类号： A61B5/05

CPC分类号： A61B5/04001

摘要： In one form of the present invention, there is provided a method for detecting an A-wave, the method comprising: applying a series of stimuli to a nerve; recording a series of late responses; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics. In another form of the present invention, there is provided a system for detecting an A-wave comprising: a stimulation electrode; a stimulation circuit connected to the stimulation electrode for applying a series of stimuli to a nerve; a detection electrode; a detection circuit connected to the detection electrode; and an analyzer connected to the detection electrode and adapted to detect an A-wave by: recording a series of late responses detected by the detection circuit; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space map that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics.

摘要翻译： 在本发明的一种形式中，提供了一种用于检测A波的方法，所述方法包括：将一系列刺激施加于神经; 录制一系列迟来的回应; 从晚期响应的集合中创建特征空间图; 识别表征A波分量的特征空间内的簇; 将A波分量合并成A波的离散集合; 去除假阳性A波; 并提取A波特性。 在本发明的另一形式中，提供了一种用于检测A波的系统，包括：刺激电极; 连接到刺激电极的刺激电路，用于将一系列刺激施加到神经上; 检测电极; 连接到检测电极的检测电路; 以及连接到所述检测电极并且适于通过以下步骤检测A波的分析器：记录由所述检测电路检测到的一系列后期响应; 从晚期响应的集合中创建特征空间图; 识别表征A波分量的特征空间图内的簇; 将A波分量合并成A波的离散集合; 去除假阳性A波; 并提取A波特性。

公开(公告)号：US09173581B2

公开(公告)日：2015-11-03

申请号：US13235258

申请日：2011-09-16

申请人： Bonniejean Boettcher ,  Marc Cryan ,  Shai N. Gozani ,  Glenn Herb ,  Xuan Kong ,  Michael Williams ,  Charles Fendrock

发明人： Bonniejean Boettcher ,  Marc Cryan ,  Shai N. Gozani ,  Glenn Herb ,  Xuan Kong ,  Michael Williams ,  Charles Fendrock

IPC分类号： A61B5/05 ,  A61B5/04 ,  A61B5/00 ,  A61B5/01

CPC分类号： A61B5/04001 ,  A61B5/01 ,  A61B5/05 ,  A61B5/4041 ,  A61B2560/0266 ,  A61B2560/028 ,  A61B2560/0425 ,  A61B2560/0468 ,  A61B2562/0209 ,  A61B2562/046

摘要： Apparatus for measuring sural nerve conduction velocity and amplitude, the apparatus including a housing; stimulation means for electrically stimulating a human sural nerve; a biosensor comprising a plurality of electrodes for detecting a sural nerve response evoked by the stimulation means; acquisition means electrically connected to the biosensor for electrically acquiring the sural nerve response detected by the biosensor; processing means electrically connected to the acquisition means for digitizing, processing and storing the acquired sural nerve response; calculation means electrically connected to the processing means for calculating the conduction velocity and amplitude of the processed sural nerve response; and display means for displaying the sural nerve conduction velocity and amplitude; wherein the stimulation means and the biosensor are designed to be placed on a patient's anatomy, in the vicinity of a sural nerve.

摘要翻译： 用于测量腓肠神经传导速度和振幅的装置，所述装置包括壳体; 用于电刺激人类腓肠神经的刺激装置; 生物传感器，包括用于检测由所述刺激装置引起的腓肠神经反应的多个电极; 电连接到所述生物传感器以获取由所述生物传感器检测到的所述腓肠神经反应的获取装置; 电连接到所述获取装置的数字化，处理和存储所获取的腓肠神经反应的处理装置; 电连接到处理装置的计算装置，用于计算处理的腓肠神经反应的传导速度和振幅; 以及用于显示腓肠神经传导速度和振幅的显示装置; 其中所述刺激装置和所述生物传感器被设计成放置在腓肠神经附近的患者解剖结构上。

公开(公告)号：US20120101358A1

公开(公告)日：2012-04-26

申请号：US13235258

申请日：2011-09-16

申请人： Bonniejean Boettcher ,  Marc Cryan ,  Shai N. Gozani ,  Glenn Herb ,  Xuan Kong ,  Michael Williams ,  Charles Fendrock

发明人： Bonniejean Boettcher ,  Marc Cryan ,  Shai N. Gozani ,  Glenn Herb ,  Xuan Kong ,  Michael Williams ,  Charles Fendrock

IPC分类号： A61B5/05 ,  G06F17/00

CPC分类号： A61B5/04001 ,  A61B5/01 ,  A61B5/05 ,  A61B5/4041 ,  A61B2560/0266 ,  A61B2560/028 ,  A61B2560/0425 ,  A61B2560/0468 ,  A61B2562/0209 ,  A61B2562/046

摘要： Apparatus comprising a housing; stimulation means mounted to the housing; a biosensor releasably mounted to the housing, the biosensor comprising a plurality of electrodes for detecting a sural nerve response evoked by the stimulation means; acquisition means mounted to the housing and electrically connected to the biosensor for acquiring the sural nerve response; processing means mounted to the housing and electrically connected to the acquisition means for digitizing, processing and storing the acquired sural nerve response; calculation means mounted to the housing and electrically connected to the processing means for calculating the conduction velocity and amplitude of the processed sural nerve response; and display means mounted to the housing for displaying the sural nerve conduction velocity and amplitude; wherein the stimulation means and the biosensor are designed to be placed on a patient's anatomy, in the vicinity of a sural nerve, by manipulating the housing.

摘要翻译： 一种装置，包括壳体; 刺激装置安装到壳体; 所述生物传感器包括多个用于检测由所述刺激装置引起的腓肠神经反应的电极; 获取装置，安装到壳体并电连接到生物传感器以获取腓肠神经反应; 处理装置安装到壳体并电连接到采集装置，用于数字化，处理和存储所获取的腓肠神经反应; 计算装置安装到壳体并电连接到处理装置，用于计算处理的腓肠神经反应的传导速度和幅度; 以及显示装置，安装到所述壳体以显示所述腓肠神经传导速度和振幅; 其中所述刺激装置和所述生物传感器被设计成通过操纵所述壳体而放置在腓肠神经附近的患者解剖结构上。