公开(公告)号：US10669249B2

公开(公告)日：2020-06-02

申请号：US16309807

申请日：2016-07-21

申请人： Shandong Luye Pharmaceutical Co., Ltd.

发明人： Mina Yang ,  Yongtao Jiang ,  Ying Meng ,  Tao Wang ,  Qian qian Xu ,  Xin Shao ,  Chunjie Sha

IPC分类号： C07D333/10

摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.

公开(公告)号：US11111227B2

公开(公告)日：2021-09-07

申请号：US16860037

申请日：2020-04-27

申请人： Shandong Luye Pharmaceutical Co., Ltd.

发明人： Mina Yang ,  Yongtao Jiang ,  Ying Meng ,  Tao Wang ,  Qian qian Xu ,  Xin Shao ,  Chunjie Sha

IPC分类号： C07D333/10

摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.