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公开(公告)号：US12030939B2
公开(公告)日：2024-07-09
申请号：US17290401
申请日：2019-09-26
发明人： Qiang Li , Shixiang Jia , Lili Zhao , Guimin Zhang , Zhong Liu , Xinlu Ma , Yuan Yan , Zhenyu Li , Xingxia Hu , Yuhua Zhang , Bin Li
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28 , C07K16/32 , C07K16/46 , C12N15/62 , C12N15/85 , A61K39/00
CPC分类号： C07K16/2809 , A61K39/3955 , A61K45/06 , A61P35/00 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/3007 , C07K16/303 , C07K16/32 , C07K16/468 , C12N15/62 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention provided herein relates to methods and uses of a bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests.
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公开(公告)号：US20230416385A1
公开(公告)日：2023-12-28
申请号：US17290401
申请日：2019-09-26
发明人： Qiang Li , Shixiang Jia , Lili Zhao , Guimin Zhang , Zhong Liu , Xinlu Ma , Yuan Yan , Zhenyu Li , Xingxia Hu , Yuhua Zhang , Bin Li
CPC分类号： C07K16/2878 , C07K16/2809 , A61P35/00 , A61K2039/505 , C07K2317/622 , C07K2317/33 , C07K2317/31
摘要： A bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests. The method for constructing a bispecific antibody is simple, and avoids the possibility of mismatching between two sets of light chains and heavy chains of a heterologous bispecific antibody, thus the difficulty of antibody purification is reduced, the affinity of the obtained antibody is high, the side effects of induced cytokines are few, and safety is high.
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公开(公告)号：US20240301063A1
公开(公告)日：2024-09-12
申请号：US18671707
申请日：2024-05-22
发明人： Qiang Li , Shixiang Jia , Lili Zhao , Guimin Zhang , Zhong Liu , Xinlu Ma , Yuan Yan , Zhenyu Li , Xingxia Hu , Yuhua Zhang , Bin Li
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/30 , C07K16/32 , C07K16/46 , C12N15/62 , C12N15/85
CPC分类号： C07K16/2809 , A61K39/3955 , A61K45/06 , A61P35/00 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/3007 , C07K16/303 , C07K16/32 , C07K16/468 , C12N15/62 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention provided herein relates to methods and uses of a bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests.
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