公开(公告)号：US20110020404A1

公开(公告)日：2011-01-27

申请号：US12673798

申请日：2008-08-18

申请人： Shane A. Olwill ,  James A. Johnston ,  Hang Fai Kwok ,  Clare Whelan ,  John Clarke

发明人： Shane A. Olwill ,  James A. Johnston ,  Hang Fai Kwok ,  Clare Whelan ,  John Clarke

IPC分类号： A61K39/04 ,  C12Q1/04 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/68 ,  A61P31/06

CPC分类号： G01N33/5695 ,  A61K39/04

摘要： The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising (i) the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, and ESAT 6 antigen; or (ii) at least seven of the antigens of the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, ESAT 6 antigen, CFP10 antigen, α crystalline 2 antigen, PE35 antigen, and PPE68 antigen. Also provided is a method for the diagnosis of the presence of tuberculosis in a reservoir animal e.g. a badger, said method comprising determining the presence or absence of, or an immune response to Rv3616 antigen, MPB70 antigen, and MPB83 antigen. Kits for carrying out the methods are also provided.

摘要翻译： 本发明涉及用于诊断动物结核病的方法，所述方法包括确定对抗原组的存在或不存在或免疫应答，所述抗原组包含（i）由Rv3616抗原，MPB70抗原，MPB83抗原和 ESAT 6抗原; 或（ii）由Rv3616抗原，MPB70抗原，MPB83抗原，ESAT6抗原，CFP10抗原，α结晶2抗原，PE35抗原和PPE68抗原组成的组中的至少7种抗原。 还提供了用于诊断储存动物中结核病存在的方法，例如， 所述方法包括确定Rv3616抗原，MPB70抗原和MPB83抗原的存在或不存在或免疫应答。 还提供了实施方法的工具包。