公开(公告)号：US20230348471A1

公开(公告)日：2023-11-02

申请号：US18002133

申请日：2021-06-18

申请人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd. ,  Zhejiang Huahai Pharmaceutical Co., Ltd.

发明人： Xin Xu ,  Jia Chen ,  Guan Wang ,  Linli Zhang ,  Qingyun Jiang ,  Chenghao Xi ,  Kang Sun ,  Xiaojuan Zhang ,  Chunqiao Chen ,  Shuai Li ,  Qiang Li ,  Liangze Xia ,  Ying Wang ,  Xiaoer Xia

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P35/00 ,  A61P19/02 ,  A61P11/00 ,  A61P37/06

CPC分类号： C07D487/04 ,  C07D519/00 ,  A61P35/00 ,  A61P19/02 ,  A61P11/00 ,  A61P37/06

摘要： A type of Bruton's tyrosine kinase inhibitor, a preparation method therefor, and an application thereof in the field of medicine. The Bruton's tyrosine kinase inhibitor may be used for preventing and/or treating a disease related to Bruton's tyrosine kinase mediation, such as an autoimmune disease, cancer, or an inflammatory disease. Through experimental research, the provided compound has high selectivity with respect to a Bruton's tyrosine kinase target, and can exhibit a uniquely advantageous medicinal effect in an in vivo animal experiment.