公开(公告)号：US20230203022A1

公开(公告)日：2023-06-29

申请号：US17922124

申请日：2021-04-29

Applicant: Shanghaitech University

Inventor： Xiaobao YANG ,  Biao JIANG ,  Linyi LIU ,  Chaowei REN ,  Xing QIU ,  Haixia LIU ,  Ning SUN ,  Renhong SUN

IPC: C07D405/14 ,  A61K45/06 ,  C07D417/14 ,  C07D401/14 ,  C07D453/02 ,  C07D409/14

CPC classification number: C07D405/14 ,  A61K45/06 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D453/02

Abstract: The present disclosure relates to compounds of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The present disclosure also relates to pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and use thereof. A series of compounds designed and synthesized by the present disclosure can effectively prevent and/or treat diseases or disorders associated with TNF-a.

公开(公告)号：US20230303539A1

公开(公告)日：2023-09-28

申请号：US18021334

申请日：2021-08-12

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Xiaobao YANG ,  Biao JIANG ,  Linyi LIU ,  Chaowei REN ,  Xing QIU

IPC: C07D405/14 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D401/04 ,  C07D417/14

CPC classification number: C07D405/14 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D401/04 ,  C07D417/14

Abstract: The present disclosure provides compounds of formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and applications thereof, and pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and applications of the pharmaceutical compositions. The compounds can effectively prevent and/or treat diseases or disorders associated with TNF-α.

公开(公告)号：US20220143002A1

公开(公告)日：2022-05-12

申请号：US17433462

申请日：2020-02-25

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Xiaobao YANG ,  Biao JIANG ,  Xing QIU ,  Ning SUN ,  Renhong SUN ,  Linyi LIU ,  Chaowei REN

IPC: A61K31/4545 ,  A61P35/00 ,  C07D401/04 ,  A61K31/454 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D491/107 ,  C07D471/08 ,  A61K31/55 ,  A61K31/551 ,  C07D413/14 ,  A61K31/541 ,  A61K31/517 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  C07D409/14 ,  A61K31/4709 ,  A61K45/06

Abstract: The present disclosure relates to a compound of Formula (I) or a salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor. The present disclosure also relates to a compound of Formula (I′) or a pharmaceutically acceptable salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor.