公开(公告)号：US20230203022A1

公开(公告)日：2023-06-29

申请号：US17922124

申请日：2021-04-29

Applicant: Shanghaitech University

Inventor： Xiaobao YANG ,  Biao JIANG ,  Linyi LIU ,  Chaowei REN ,  Xing QIU ,  Haixia LIU ,  Ning SUN ,  Renhong SUN

IPC: C07D405/14 ,  A61K45/06 ,  C07D417/14 ,  C07D401/14 ,  C07D453/02 ,  C07D409/14

CPC classification number: C07D405/14 ,  A61K45/06 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D453/02

Abstract: The present disclosure relates to compounds of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The present disclosure also relates to pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and use thereof. A series of compounds designed and synthesized by the present disclosure can effectively prevent and/or treat diseases or disorders associated with TNF-a.

公开(公告)号：US20220313829A1

公开(公告)日：2022-10-06

申请号：US17632612

申请日：2020-08-05

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Xiaobao YANG ,  Biao JIANG ,  Xiaoling SONG ,  Ning SUN ,  Chaowei REN ,  Renhong SUN ,  Xiaojuan QU ,  Haixia LIU ,  Xing QIU

IPC: A61K47/55 ,  A61K47/54 ,  A61P35/00

Abstract: A bifunctional compound, or a pharmaceutically acceptable salt, an isomer, a prodrug, a polymorphic substance or a solvate thereof. The chemical structural formula of the bifunctional compound is represented as formula I, and the bifunctional compound can be used for preventing or treating cancers.