公开(公告)号：US5869055A

公开(公告)日：1999-02-09

申请号：US484397

申请日：1995-06-07

申请人： Shao-Chieh Juan ,  Henri S. Lichenstein ,  Samuel D. Wright

发明人： Shao-Chieh Juan ,  Henri S. Lichenstein ,  Samuel D. Wright

IPC分类号： A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention relates to anti-inflammatory polypeptides comprising soluble CD14 related polypeptides having amino acids at position 7-10 that are different from the native sequence or having amino acids 1-14 deleted.

摘要翻译： 本发明涉及包含可溶性CD14相关多肽的抗炎多肽，其具有不同于天然序列或缺失氨基酸1-14的位置7-10的氨基酸。

公开(公告)号：US5766593A

公开(公告)日：1998-06-16

申请号：US366953

申请日：1994-12-30

申请人： Henri S. Lichenstein ,  Samuel D. Wright ,  Linda O. Narhi ,  Shao-Chieh Juan

发明人： Henri S. Lichenstein ,  Samuel D. Wright ,  Linda O. Narhi ,  Shao-Chieh Juan

IPC分类号： A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.

摘要翻译： 本发明涉及基于CD14的肽区7-10,11-14和57-64的抗炎肽。

公开(公告)号：US06512104B1

公开(公告)日：2003-01-28

申请号：US08724378

申请日：1996-10-01

申请人： Shao-Chieh Juan ,  Frederick A. Fletcher ,  Scott D. Patterson

发明人： Shao-Chieh Juan ,  Frederick A. Fletcher ,  Scott D. Patterson

IPC分类号： C07H2104

CPC分类号： C12N9/6475 ,  A61K38/00

摘要： A new member of a family of ICE-like cysteine proteases has been identified. The protease family is termed LICE (Like ICE) and the family member described herein is LICE3. LICE3 polypeptides, nucleic acids encoding LICE3 and vectors and host cells for the expression LICE3 are disclosed. Also disclosed are methods for identifying LICE3 agonists and antagonists, and methods for treatment of disorders characterized by altered apoptosis.