公开(公告)号：US5230896A

公开(公告)日：1993-07-27

申请号：US420963

申请日：1989-10-12

申请人： Sharlin E. Yeh ,  Niranjan Patel ,  Josephine Milstone

发明人： Sharlin E. Yeh ,  Niranjan Patel ,  Josephine Milstone

IPC分类号： A61K9/70 ,  A61K31/465

CPC分类号： A61K9/7061 ,  A61K31/465

摘要： A novel transdermal delivery system for nicotine to satisfy addicted smokers' cravings therefore is comprised of a nicotine base, an acrylate polymer adhesive, a stabilizer and a polyester film backing. The nicotine is absorbed through the skin at sufficiently high levels to reduce or eliminate the desire to smoke, yet its concentration within the acrylate matrix is such that a laminar patch is constructed that is neither bulky nor obvious when worn. A method of manufacture of the transdermal system is also described.

摘要翻译： 因此，尼古丁的一种新型透皮递送系统由尼古丁碱，丙烯酸酯聚合物粘合剂，稳定剂和聚酯薄膜背衬构成，以满足上瘾吸烟者的渴望。 尼古丁通过皮肤以足够高的水平吸收，以减少或消除吸烟欲望，但是其在丙烯酸酯基质内的浓度使得构成层状贴片，其在穿戴时既不庞大也不明显。 还描述了透皮系统的制造方法。

公开(公告)号：US6043407A

公开(公告)日：2000-03-28

申请号：US119866

申请日：1998-07-21

申请人： Shahid Amir Lodhi ,  Josephine Milstone

发明人： Shahid Amir Lodhi ,  Josephine Milstone

IPC分类号： A61L15/38 ,  A61F13/00

CPC分类号： A61L15/38

摘要： A debridement pad is provided having fibrinolysin enzyme, desoxyribonuclease enzyme and cellulosic material in the form of a lyophilized sponge-like pad. Placement of the pad over an open wound produces a gel which has a protective effect and which releases the enzymes directly into the wound. The pad may also contain antibiotic agents.

摘要翻译： 提供了具有纤维蛋白酶，脱氧核糖核酸酶和纤维素材料的清创垫，其为冻干海绵状垫的形式。 将垫放置在开放的伤口上，产生具有保护作用并将酶直接释放到伤口中的凝胶。 垫也可以含有抗生素。