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公开(公告)号：US20090028822A1
公开(公告)日：2009-01-29
申请号：US11659942
申请日：2005-09-12
申请人： Shawn DeFrees , David A. Zopf , Henrik Clausen , Ruye Xing
发明人： Shawn DeFrees , David A. Zopf , Henrik Clausen , Ruye Xing
CPC分类号： A61K38/212 , A61K47/60 , Y02A50/463 , Y02A50/473
摘要： The present invention provides IFN-α conjugates including IFN-α peptides and modifying groups such as PEG moieties. The IFN-α peptide and modifying group are linked via an intact glycosyl linking group interposed between and covalently attached to the IFN-α peptide and the modifying group. The IFN-α conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar onto an amino acid or a glycosyl residue on the IFN-α peptide. Also provided are methods for preparing the IFN-α conjugates, methods for treating various disease conditions with the IFN-α conjugates, and pharmaceutical formulations including the IFN-α conjugates.
摘要翻译： 本发明提供IFN-α缀合物，包括IFN-α肽和修饰基团例如PEG部分。 IFN-α肽和修饰基团通过介于IFN-α肽和修饰基团之间并共价连接的完整糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成IFN-α缀合物。 糖基转移酶将修饰的糖连接到IFN-α肽上的氨基酸或糖基残基上。 还提供了用于制备IFN-α缀合物的方法，用IFN-α缀合物治疗各种疾病状况的方法，以及包括IFN-α缀合物的药物制剂。
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公开(公告)号：US08268967B2
公开(公告)日：2012-09-18
申请号：US11659942
申请日：2005-09-12
申请人： Shawn DeFrees , David A. Zopf , Henrik Clausen , Ruye Xing
发明人： Shawn DeFrees , David A. Zopf , Henrik Clausen , Ruye Xing
CPC分类号： A61K38/212 , A61K47/60 , Y02A50/463 , Y02A50/473
摘要： The present invention provides IFN-α conjugates including IFN-α peptides and modifying groups such as PEG moieties. The IFN-α peptide and modifying group are linked via an intact glycosyl linking group interposed between and covalently attached to the IFN-α peptide and the modifying group. The IFN-α conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar onto an amino acid or a glycosyl residue on the IFN-α peptide. Also provided are methods for preparing the IFN-α conjugates, methods for treating various disease conditions with the IFN-α conjugates, and pharmaceutical formulations including the IFN-α conjugates.
摘要翻译： 本发明提供IFN-α缀合物，包括IFN-α肽和修饰基团例如PEG部分。 IFN-α肽和修饰基团通过介于IFN-α肽和修饰基团之间并共价连接的完整糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成IFN-α缀合物。 糖基转移酶将修饰的糖连接到IFN-α肽上的氨基酸或糖基残基上。 还提供了制备IFN-α缀合物的方法，用IFN-α缀合物治疗各种疾病状况的方法，以及包括IFN-α缀合物的药物制剂。
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公开(公告)号：US07083809B2
公开(公告)日：2006-08-01
申请号：US10364593
申请日：2003-02-11
IPC分类号： A61K35/54
CPC分类号： A61K35/57 , Y02A50/411
摘要： Disclosed is a composition comprising a substantially purified Cytokine Inhibitory Factor (CIF) having certain characteristics, including the ability to inhibit RNA transcription of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1-beta (IL-1β), and interleukin-2 (IL-2). Also disclosed is a method for substantially purifying the Cytokine Inhibitory Factor and a method for modulating the immune system of an animal using such composition.
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公开(公告)号：US06420337B1
公开(公告)日：2002-07-16
申请号：US09620093
申请日：2000-07-20
申请人： Subramanian Iyer , Tay N. Nguyen , Dauh-Rurng Wu , Ruye Xing
发明人： Subramanian Iyer , Tay N. Nguyen , Dauh-Rurng Wu , Ruye Xing
IPC分类号： A01N3718
CPC分类号： C07K14/465 , A61K38/00 , C07K14/46 , Y10S530/853
摘要： Disclosed is an isolated Cytokine Activating Factor (CAF) protein, an isolated nucleic acid molecule encoding a CAF protein, an antibody that selectively binds to a CAF protein, a composition comprising a Cytokine Activating Factor (CAF), and a method for modulating the immune system using the composition. Also disclosed is a method for treating cancer using such a composition.
摘要翻译： 公开了分离的细胞因子激活因子（CAF）蛋白，编码CAF蛋白的分离的核酸分子，选择性结合CAF蛋白的抗体，包含细胞因子激活因子（CAF）的组合物和调节免疫的方法 系统使用组合。 还公开了使用这种组合物治疗癌症的方法。
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