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    Methods of manufacturing crystalline forms of rapamycin analogs
    2.
    发明授权
    Methods of manufacturing crystalline forms of rapamycin analogs 有权
    制备雷帕霉素类似物结晶形式的方法

    公开(公告)号：US08034926B2

    公开(公告)日：2011-10-11

    申请号：US12886398

    申请日：2010-09-20

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    Methods of manufacturing crystalline forms of rapamycin analogs
    3.
    发明授权
    Methods of manufacturing crystalline forms of rapamycin analogs 有权
    制备雷帕霉素类似物结晶形式的方法

    公开(公告)号：US07820812B2

    公开(公告)日：2010-10-26

    申请号：US11781807

    申请日：2007-07-23

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    METHODS OF MANUFACTURING CRYSTALLING FORMS OF RAPAMYCIN ANALOGS
    4.
    发明申请
    METHODS OF MANUFACTURING CRYSTALLING FORMS OF RAPAMYCIN ANALOGS 有权
    制备RAPAMYCIN模拟物的结晶形式的方法

    公开(公告)号：US20110009618A1

    公开(公告)日：2011-01-13

    申请号：US12886398

    申请日：2010-09-20

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D498/16

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    Methods of Manufacturing Crystalline Forms of Rapamycin Analogs
    5.
    发明申请
    Methods of Manufacturing Crystalline Forms of Rapamycin Analogs 审中-公开
    雷帕霉素类似物的结晶形式的制备方法

    公开(公告)号：US20120028908A1

    公开(公告)日：2012-02-02

    申请号：US13251207

    申请日：2011-10-01

    申请人： Shekhar VISWANATH ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar VISWANATH ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： A61K38/16 ,  A61K31/437 ,  A61K31/7048 ,  A61P35/00 ,  A61K31/565 ,  A61K31/56 ,  C07D498/12 ,  A61K31/5365 ,  A61K31/573

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。

    METHODS OF MANUFACTURING CRYSTALLINE FORMS OF RAPAMYCIN ANALOGS
    8.
    发明申请
    METHODS OF MANUFACTURING CRYSTALLINE FORMS OF RAPAMYCIN ANALOGS 有权
    制备RAPAMYCIN模拟物的结晶形式的方法

    公开(公告)号：US20080091008A1

    公开(公告)日：2008-04-17

    申请号：US11781807

    申请日：2007-07-23

    申请人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    发明人： Shekhar Viswanath ,  Larry Bartelt ,  Robert Leanna ,  Michael Rasmussen ,  Madhup Dhaon ,  Rodger Henry ,  Thomas Borchardt ,  Shuang Chen ,  Geoff Zhang

    IPC分类号： C07D267/22

    CPC分类号： C07D498/18

    摘要： A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.

    摘要翻译： 制备结晶雷帕霉素类似物的方法包括：将雷帕霉素类似物与有机介质结合以形成混合物; 孵育混合物直到雷帕霉素类似物结晶; 并回收结晶雷帕霉素类似物。 有机介质可以是溶剂，并且该方法可以包括使雷帕霉素类似物溶解到溶剂中，并将溶剂温育直到雷帕霉素类似物结晶。 还可以进行以下操作：形成结晶雷帕霉素类似物的浆液; 搅拌雷帕霉素类似物混合物直到雷帕霉素类似物结晶; 饱和雷帕霉素类似物溶液; 形成过饱和雷帕霉素类似物溶液; 将抗溶剂与雷帕霉素类似物和溶剂组合以形成双相混合物，并将两相混合物温育以引起液 - 液相分裂。