POLYMORPH OF BENZAMIDE COMPOUND AND PREPARATION METHOD AND APPLICATIONS THEREOF

    公开(公告)号:US20190144418A1

    公开(公告)日:2019-05-16

    申请号:US16306970

    申请日:2017-07-27

    IPC分类号: C07D401/04 A01N43/56

    摘要: The present invention provides a polymorph of a benzamide compound and a preparation method and applications thereof. The shown benzamide compound is 3-Bromo-N-[2,4-dichloro-6-[(methylamino)carbonyl]phenyl]-1-(3,5-dichloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. The application of the polymorph of the compound in the preparation of the formulation exhibits excellent effect. The advantages of the polymorph A in aspects such as chemical stability, filterability, solubility, hygroscopicity, melting point, solid density and flowability can have a significant impact on the developments of the production method and a formulation and on the quality and efficacy of a plant treating agent.

    METHOD OF PREPARING MALONONITRILE OXIME ETHER COMPOUND AND INTERMEDIATE COMPOUND

    公开(公告)号:US20220055996A1

    公开(公告)日:2022-02-24

    申请号:US17259565

    申请日:2019-06-17

    摘要: Provided are a method of preparing a malononitrile oxime ether compound and an intermediate compound. The malononitrile oxime ether compound has a structure as shown in formula (VII), wherein W is selected from aryl or heteroaryl. The preparation method comprises steps: reacting a first raw material with a second raw material in the presence of a first solvent and a catalyst to obtain the intermediate compound, wherein the first raw material has a structure as shown in formula (IV), and the second raw material has a structure as shown in formula (V); and subjecting the intermediate compound as shown in formula (VI), and, a dehyclrant to a dehydrantion reaction in the presence of a second solvent to obtain the malononitrile oxime ether compound. In the preparation process for the intermediate, a cheaper cyanoacetamide is used as a raw material, the reaction conditions are mild. Moreover, the yield of the intermediate compound is high and the cost of the process is low. Furthermore, the required malononitrile oxime ether compound, is obtained only through one-step dehydration reaction. Using the preparation method, is advantageous for improving the yield of malononitrile oxime ethers and reducing the cost of the process.

    LIQUID FORMULATION OF BIPHENYL-CONTAINING COMPOUND AND APPLICATION THEREOF

    公开(公告)号:US20210176988A1

    公开(公告)日:2021-06-17

    申请号:US17187877

    申请日:2021-02-28

    摘要: The present invention belongs to the field of acaricides, and relates to a liquid formulation of a biphenyl-containing compound and an application thereof. A liquid formulation of a biphenyl-containing compound takes compound A as an active component and comprises at least one carrier and at least one auxiliary. The weight percentage of the active component in the liquid formulation is 0.1%-99%. The liquid formulation of the present invention can control the particle size of the liquid formulation through a good auxiliary system, and has the characteristics of good dispersibility, high suspension rate, good biological activity, low dosage, low cost, resistance to rain washing, low residue and low toxicity to people and animals.