公开(公告)号：US06605284B2

公开(公告)日：2003-08-12

申请号：US09873233

申请日：2001-06-05

申请人： Shigeharu Ueda ,  Michiko Watanabe ,  Hitomi Kawanish

发明人： Shigeharu Ueda ,  Michiko Watanabe ,  Hitomi Kawanish

IPC分类号： A61K37165

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/525 ,  A61K2039/53 ,  C12N2760/18422

摘要： Disclosed is a measles virus mutant gene coding for a measles virus mutant H protein antigen, wherein said gene coding for a measles virus mutant H protein antigen is at least one member selected from the group consisting of the following genes (a) to (c): (a) a gene coding for an amino acid sequence of SEQ ID NO: 10; (b) a gene coding for an amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 11; and (c) a gene coding for an amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 12. By the use of the measles virus mutant gene of the present invention, it has become possible to provide efficiently and economically a gene vaccine which is adapted for an epidemic strain of measles virus, and a diagnostic reagent capable of accurately detecting infections with an epidemic strain of measles virus.

摘要翻译： 公开了编码麻疹病毒突变型H蛋白抗原的麻疹病毒突变基因，其中编码麻疹病毒突变型H蛋白抗原的所述基因是选自以下基因（a）〜（c）中的至少一种， ：（a）编码SEQ ID NO：10的氨基酸序列的基因; （b）编码SEQ ID NO：3或SEQ ID NO：11的氨基酸序列的基因; 和（c）编码SEQ ID NO：4或SEQ ID NO：12的氨基酸序列的基因。通过使用本发明的麻疹病毒突变基因，已经有可能高效地和经济地提供基因 适用于麻疹病毒流行病毒的疫苗，以及能够准确检测麻疹病毒流行病毒感染的诊断试剂。

公开(公告)号：US06277380B1

公开(公告)日：2001-08-21

申请号：US09230944

申请日：1999-02-04

申请人： Shigeharu Ueda ,  Michiko Watanabe ,  Hitomi Kawanish

发明人： Shigeharu Ueda ,  Michiko Watanabe ,  Hitomi Kawanish

IPC分类号： A61K39165

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  A61K2039/525 ,  A61K2039/53 ,  C12N2760/18422

摘要： Disclosed is a measles virus mutant antigen consisting essentially of a measles virus mutant H protein antigen, wherein said measles virus mutant H protein antigen is at least one member selected from the group consisting of the following amino acid sequences (a) to (c): (a) an amino acid sequence of SEQ ID NO: 10; (b) an amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 11; and (c) an amino acid sequence of SEQ ID NO. 4 or SEQ ID NO: 12 By the use of the measles virus mutant antigen of the present invention, it has become possible to provide efficiently and economically a live attenuated measles vaccine which is adapted for an epidemic strain of measles virus, and a diagnostic reagent capable of accurately detecting infections with an epidemic strain of measles virus.

摘要翻译： 公开了基本上由麻疹病毒突变H蛋白抗原组成的麻疹病毒突变抗原，其中所述麻疹病毒突变H蛋白抗原是选自以下氨基酸序列（a）至（c）中的至少一个： （a）SEQ ID NO：10的氨基酸序列; （b）SEQ ID NO：3或SEQ ID NO：11的氨基酸序列; 和（c）SEQ ID NO：1的氨基酸序列。 4或SEQ ID NO：12通过使用本发明的麻疹病毒突变抗原，已经有可能有效地和经济地提供适用于麻疹病毒流行株的活减毒麻疹疫苗和诊断试剂 能够准确检测麻疹病毒流行株的感染。