公开(公告)号：US07801352B2

公开(公告)日：2010-09-21

申请号：US11477822

申请日：2006-06-30

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

IPC分类号： G06K9/00

CPC分类号： G02B21/367

摘要： In acquisition of a micro image of a sample S by a micro image acquiring unit, when a plurality of image acquiring ranges are set for the sample S as an object of image acquisition, a plurality of corresponding focus information are set, and furthermore, when a plurality of partial images acquired by scanning the sample S by the micro image acquiring unit include a partial image including mixing of a plurality of image acquiring ranges, the focus information is switched in the middle of scanning of the partial image. With such a structure, even when a plurality of objects are contained in the sample S, images of the respective objects can be preferably acquired. Thereby, an image acquiring apparatus, an image acquiring method, and an image acquiring program which are capable of preferably acquiring images of a plurality of objects are realized even when the plurality of objects are contained in a sample S.

摘要翻译： 在通过微图像获取单元获取样本S的微图像时，当为作为图像获取对象的样本S设置多个图像获取范围时，设置多个对应的焦点信息，此外，当 通过由微图像获取单元扫描样本S获取的多个部分图像包括包括多个图像获取范围的混合的部分图像，在部分图像的扫描中间切换焦点信息。 通过这样的结构，即使在样本S中包含多个物体，也可以优选获得各个物体的图像。 因此，即使当多个对象被包含在样本S中时，也能够实现能够优选地获取多个对象的图像的图像获取装置，图像获取方法和图像获取程序。

公开(公告)号：US20070206097A1

公开(公告)日：2007-09-06

申请号：US11477822

申请日：2006-06-30

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

IPC分类号： H04N5/225

CPC分类号： G02B21/367

摘要： In acquisition of a micro image of a sample S by a micro image acquiring unit 30, when a plurality of image acquiring ranges are set for the sample S as an object of image acquisition, a plurality of corresponding focus information are set, and furthermore, when a plurality of partial images acquired by scanning the sample S by the micro image acquiring unit 30 include a partial image including mixing of a plurality of image acquiring ranges, the focus information is switched in the middle of scanning of the partial image. With such a structure, even when a plurality of objects are contained in the sample S, images of the respective objects can be preferably acquired. Thereby, an image acquiring apparatus, an image acquiring method, and an image acquiring program which are capable of preferably acquiring images of a plurality of objects are realized even when the plurality of objects are contained in a sample S.

摘要翻译： 在通过微图像获取单元30获取样本S的微图像时，当为作为图像获取对象的样本S设置多个图像采集范围时，设置多个相应的焦点信息，此外， 当通过微图像获取单元30扫描样本S获取的多个部分图像包括包括多个图像获取范围的混合的部分图像时，在部分图像的扫描中间切换焦点信息。 通过这样的结构，即使在样本S中包含多个物体，也可以优选获得各个物体的图像。 因此，即使当多个对象被包含在样本S中时，也能够实现能够优选地获取多个对象的图像的图像获取装置，图像获取方法和图像获取程序。

公开(公告)号：US07978898B2

公开(公告)日：2011-07-12

申请号：US12857110

申请日：2010-08-16

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa ,  Jeremy Cooke

IPC分类号： G06K9/00

CPC分类号： G02B21/367

摘要： In acquisition of a micro image of a sample by a micro image acquiring unit, when a plurality of image acquiring ranges are set for the sample as an object of image acquisition, a plurality of corresponding focus information are set, and furthermore, when a plurality of partial images acquired by scanning the sample by the micro image acquiring unit include a partial image including mixing of a plurality of image acquiring ranges, the focus information is switched in the middle of scanning of the partial image. With such a structure, even when a plurality of objects are contained in the sample, images of the respective objects can be preferably acquired. Thereby, an image acquiring apparatus, an image acquiring method, and an image acquiring program which are capable of preferably acquiring images of a plurality of objects are realized even when the plurality of objects are contained in a sample.

摘要翻译： 在通过微图像获取单元获取样本的微图像时，当为样本设置多个图像采集范围作为图像获取对象时，设置多个对应的焦点信息，此外，当多个 通过由微图像获取单元扫描样本而获取的部分图像包括包括多个图像获取范围的混合的部分图像，在部分图像的扫描中间切换焦点信息。 利用这种结构，即使在样本中包含多个对象，也可以优选地获取各个对象的图像。 因此，即使当多个对象被包含在样本中时，也能够实现能够优选地获取多个对象的图像的图像获取装置，图像获取方法和图像获取程序。

公开(公告)号：US08422127B2

公开(公告)日：2013-04-16

申请号：US11886255

申请日：2006-03-17

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

IPC分类号： G02B21/00

CPC分类号： G02B21/241 ,  G02B21/26 ,  G02B21/365

摘要： The present invention relates to a microscopic image capturing apparatus having a structure that, in scanning an imageable area of an imaging unit in a predetermined direction in an imaging object area, in which a sample is present, can reliably set a focal point of the imaging unit on each imaging position set inside the imaging object area regardless of the type of focusing actuator. The microscopic image capturing apparatus has a sample setting stage having a sample setting surface that is inclined with respect to a scan plane orthogonal to an optical axis of an objective lens. By moving the sample setting stage along the scan plane such that the distance in the optical axis direction between the imaging unit and the sample setting surface varies monotonously, the focal point position of the imaging unit is adjusted in only one direction along the optical axis of the objective lens.

摘要翻译： 本发明涉及一种显微图像拍摄装置，其特征在于，在成像对象区域内，在成像对象区域内，在成像单元的预定方向的可成像区域中进行扫描时，能够可靠地设定成像的焦点 在成像对象区域内设置的每个成像位置上的单位，而与聚焦致动器的类型无关。 微观图像拍摄装置具有样品设定台，该样品设定台具有相对于与物镜的光轴正交的扫描面倾斜的样品设定面。 通过沿着扫描平面移动样品设定台，使得成像单元和样品设定面之间的光轴方向上的距离单调变化，则成像单元的焦点位置仅在沿着 物镜。

公开(公告)号：US20090002811A1

公开(公告)日：2009-01-01

申请号：US11886255

申请日：2006-03-17

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

IPC分类号： G02B21/26 ,  G02B21/36

CPC分类号： G02B21/241 ,  G02B21/26 ,  G02B21/365

摘要： The present invention relates to a microscopic image capturing apparatus having a structure that, in scanning an imageable area of an imaging unit in a predetermined direction in an imaging object area, in which a sample is present, can reliably set a focal point of the imaging unit on each imaging position set inside the imaging object area regardless of the type of focusing actuator. The microscopic image capturing apparatus has a sample setting stage having a sample setting surface that is inclined with respect to a scan plane orthogonal to an optical axis of an objective lens. By moving the sample setting stage, which has such a sample setting surface, along the scan plane in a manner such that the distance in the optical axis direction between the imaging unit and the sample setting surface varies monotonously, the focal point position of the imaging unit is adjusted in only one direction along the optical axis of the objective lens. In this case, even when a stepping motor is applied as the focusing actuator, the occurrence of lost motion in a driving system based on the stepping motor is prevented reliably and the focal point of the imaging unit can be set reliably on each imaging position set inside the imaging object area.

摘要翻译： 本发明涉及一种显微图像拍摄装置，其特征在于，在成像对象区域内，在成像对象区域内，在成像单元的预定方向的可成像区域中进行扫描时，能够可靠地设定成像的焦点 在成像对象区域内设置的每个成像位置上的单位，而与聚焦致动器的类型无关。 微观图像拍摄装置具有样品设定台，该样品设定台具有相对于与物镜的光轴正交的扫描面倾斜的样品设定面。 通过沿着扫描平面移动具有这样的样品设定面的样品设定台，使得成像单元和样品设定面之间的光轴方向的距离单调变化，成像的焦点位置 单元沿着物镜的光轴在一个方向上被调整。 在这种情况下，即使施加步进电机作为聚焦致动器，也可以可靠地防止基于步进电动机的驱动系统中的运动的发生，并且能够可靠地将摄像部的焦点设定在各摄像位置组 在成像对象区域内。

公开(公告)号：US20080283722A1

公开(公告)日：2008-11-20

申请号：US11658499

申请日：2005-07-20

申请人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

发明人： Shigeru Uchiyama ,  Takayuki Inoue ,  Masatoshi Okugawa

IPC分类号： G02B27/64 ,  G02B21/00

CPC分类号： G02B21/367 ,  G02B7/38 ,  H04N5/23212

摘要： A microscope apparatus 1A is formed with a CCD camera 30 that acquires an image of a sample S, a light guiding optical system 20 that guides an optical image of the sample S to the camera 30, an optical system driving section 25 that drives the camera 30 and the optical system 20 to change a focal position on the sample S in a z-axis direction, and a control device 50 that includes a focal point control section 51. The focal point control section 51 calculates a first focal point measurement value from a plurality of images acquired by a first focal point measurement that is executed while continuously changing the focal position in one direction, calculates a second focal point measurement value from a plurality of images acquired by a second focal point measurement that is executed while continuously changing the focal position in a direction opposite that of the first focal point measurement, and determines an in-focus position for the sample S based on the first and second focal point measurement values. This realizes an automatic focusing device that is capable of accurately determining an in-focus position in a short time and a microscope apparatus using the same.

摘要翻译： 显微镜装置1A形成有获取样本S的图像的CCD照相机30，将样本S的光学图像引导到照相机30的导光光学系统20，驱动照相机30的光学系统驱动部25 照相机30和光学系统20，以在z轴方向上改变样本S上的焦点位置，以及包括焦点控制部分51的控制装置50.焦点控制部分51计算第一焦点测量值 从通过在一个方向连续地改变焦点位置而执行的第一焦点测量获取的多个图像中，从通过在连续变化时执行的第二焦点测量获得的多个图像计算第二焦点测量值 在与第一焦点测量相反的方向上的焦点位置，并且基于第一和第二焦点p确定样本S的对焦位置 软膏测量值。 这实现了能够在短时间内精确地确定对焦位置的自动聚焦装置和使用其的显微镜装置。

公开(公告)号：US20100188424A1

公开(公告)日：2010-07-29

申请号：US12636808

申请日：2009-12-14

申请人： Jeremy COOKE ,  Shigeru Uchiyama ,  Masafumi Oshiro

发明人： Jeremy COOKE ,  Shigeru Uchiyama ,  Masafumi Oshiro

IPC分类号： G09G5/00

CPC分类号： G02B21/367 ,  G06T5/50 ,  G06T2207/10056

摘要： The present invention is aimed at easily providing an image which is in focus at any position in the image to be an observation target of a user and is free from misalignment in the image in a virtual microscope or the like.An image outputting server 10 includes an image storing part 11 for storing a plurality of image data with different focal points taken in an imaging direction which are images of a predetermined imaging target, specified area inputting means 12 for inputting information specifying an area in the image data, focal point information obtaining means 13 for obtaining information indicating the matching degree of a focal point in a specified area of each of the plurality of image data, image selection means 14 for selecting an image data to be output from the plurality of image data on the basis of the matching degree of the focal point, and outputting means 15 for outputting the thus selected image data.

摘要翻译： 本发明旨在容易地提供一种在图像中的任何位置处聚焦的图像，以成为用户的观察目标，并且在虚拟显微镜等中的图像中没有偏移。 图像输出服务器10包括图像存储部11，用于存储具有作为预定成像对象的图像的成像方向拍摄的具有不同焦点的多个图像数据，用于输入指定图像中的区域的信息的指定区域输入装置12 数据，焦点信息获取装置13，用于获得指示多个图像数据中的每一个的指定区域中的焦点的匹配度的信息;图像选择装置14，用于从多个图像数据中选择要输出的图像数据 基于焦点的匹配度，以及用于输出这样选择的图像数据的输出装置15。

公开(公告)号：USD564417S1

公开(公告)日：2008-03-18

申请号：US29275669

申请日：2007-01-03

申请人： Shigeru Uchiyama

设计人： Shigeru Uchiyama

公开(公告)号：USD492222S1

公开(公告)日：2004-06-29

申请号：US29176811

申请日：2003-02-27

申请人： Shigeru Uchiyama

设计人： Shigeru Uchiyama

公开(公告)号：US5018428A

公开(公告)日：1991-05-28

申请号：US478759

申请日：1990-02-12

申请人： Shigeru Uchiyama ,  Katsuhiko Obata

发明人： Shigeru Uchiyama ,  Katsuhiko Obata

IPC分类号： G10H3/00

CPC分类号： G10H3/00 ,  G10H2210/066

摘要： An electronic musical instrument extracts a pitch from an input waveform signal by a pitch extracting circuit, and directs a sound source circuit to generate a musical tone at the pitch based on the extracted pitch. The sound source circuit electronically generates musical tones at the pitches according to the performance. The pitch extracting circuit obtains fundamental period of the input waveform signal by detecting the time interval (t1) between these first two zero-cross points after two positive peak points of the input waveform signal are detected, by detecting a time interval (t2) between first two zero-cross points after two negative peak points of the input signal waveform are detected, or by detecting both the time intervals (t1, t2).

摘要翻译： 电子乐器通过音调提取电路从输入波形信号中提取音调，并且引导声源电路基于所提取的音调以音高产生音调。 声源电路根据性能以间距电子地生成乐音。 音调提取电路通过检测输入波形信号的两个正峰值点之后的前两个过零点之间的时间间隔（t1），通过检测输入波形信号的时间间隔（t2），获得输入波形信号的基本周期 或者通过检测时间间隔（t1，t2）检测输入信号波形的两个负峰值之后的前两个零交叉点。