公开(公告)号：USD383075S

公开(公告)日：1997-09-02

申请号：US44974

申请日：1995-10-04

申请人： Shigeyuki Sawaguchi ,  Takenori Ryouke ,  Takumi Hirakawa ,  Jiang Yin ,  Hiroyuki Nakabe ,  Shunji Yamagata ,  Yukiko Chiba

设计人： Shigeyuki Sawaguchi ,  Takenori Ryouke ,  Takumi Hirakawa ,  Jiang Yin ,  Hiroyuki Nakabe ,  Shunji Yamagata ,  Yukiko Chiba

公开(公告)号：US20120064113A1

公开(公告)日：2012-03-15

申请号：US13269213

申请日：2011-10-07

申请人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

发明人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

IPC分类号： A61K35/76 ,  C12N7/01 ,  A61P35/00

CPC分类号： C12N7/00 ,  A61K35/768 ,  C12N2770/32332 ,  C12N2770/32361 ,  C12N2800/30 ,  C12N2840/203

摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

摘要翻译： 在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。 稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

公开(公告)号：US07814868B2

公开(公告)日：2010-10-19

申请号：US12038406

申请日：2008-02-27

申请人： Jiang Yin ,  Jozef Boros

发明人： Jiang Yin ,  Jozef Boros

IPC分类号： F22B9/18

CPC分类号： F24H1/205 ,  F24H9/0031

摘要： A fuel-fired water heater has a draft inducer fan assembly with a housing having an inlet for receiving hot combustion gases discharged from the water heater, and an outlet for discharging the combustion gases. A normally closed damper member within the housing is openable by fluid pressure force created by operation of a draft inducer fan portion of the assembly. With the damper in its open position the fan exhausts the received combustion gases through a housing outlet. When the damper closes it prevents convective outflow through the housing outlet of flue-heated air. In alternate embodiments of the assembly the fan is operative to also draw in dilution air that cools the fan motor and the discharged combustion gases, with the assembly having an internal configuration preventing convective outflow of flue-heated air through the housing dilution air inlet during standby periods of the water heater.

摘要翻译： 燃料热水器具有牵引引风机组件，其具有壳体，该壳体具有用于接收从热水器排出的热燃烧气体的入口和用于排出燃烧气体的出口。 壳体内的常闭阻尼器构件可通过由组件的通风机风扇部分的操作产生的流体压力打开。 当阻尼器处于打开位置时，风扇通过外壳出口排出接收的燃烧气体。 当风门关闭时，防止通过烟道加热空气的外壳出口的对流流出。 在组件的替代实施例中，风扇还可以吸入冷却风扇电动机和排出的燃烧气体的稀释空气，其中组件具有内部配置，防止烟道热空气在待机期间通过壳体稀释空气入口的对流流出 热水器的时期。

公开(公告)号：US20090246216A1

公开(公告)日：2009-10-01

申请号：US12405068

申请日：2009-03-16

申请人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

发明人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

IPC分类号： A61K39/13 ,  C12N7/01 ,  A61P35/00 ,  C12N7/06

CPC分类号： C12N7/00 ,  A61K35/768 ,  C12N2770/32332 ,  C12N2770/32361 ,  C12N2800/30 ,  C12N2840/203

摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

摘要翻译： 在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。 稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

公开(公告)号：US08921101B2

公开(公告)日：2014-12-30

申请号：US13269213

申请日：2011-10-07

申请人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

发明人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

IPC分类号： A61K39/12 ,  C12N7/00 ,  A61K35/76

CPC分类号： C12N7/00 ,  A61K35/768 ,  C12N2770/32332 ,  C12N2770/32361 ,  C12N2800/30 ,  C12N2840/203

摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

摘要翻译： 在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。 稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

公开(公告)号：US08066983B2

公开(公告)日：2011-11-29

申请号：US12405068

申请日：2009-03-16

申请人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

发明人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

IPC分类号： A61K39/12 ,  C12P19/33

CPC分类号： C12N7/00 ,  A61K35/768 ,  C12N2770/32332 ,  C12N2770/32361 ,  C12N2800/30 ,  C12N2840/203

摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

摘要翻译： 在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。 稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

公开(公告)号：US20090211540A1

公开(公告)日：2009-08-27

申请号：US12038406

申请日：2008-02-27

申请人： Jiang Yin ,  Jozef Boros

发明人： Jiang Yin ,  Jozef Boros

IPC分类号： F24H1/00 ,  F24H9/20

CPC分类号： F24H1/205 ,  F24H9/0031

摘要： A fuel-fired water heater has a draft inducer fan assembly with a housing having an inlet for receiving hot combustion gases discharged from the water heater, and an outlet for discharging the combustion gases. A normally closed damper member within the housing is openable by fluid pressure force created by operation of a draft inducer fan portion of the assembly. With the damper in its open position the fan exhausts the received combustion gases through a housing outlet. When the damper closes it prevents convective outflow through the housing outlet of flue-heated air. In alternate embodiments of the assembly the fan is operative to also draw in dilution air that cools the fan motor and the discharged combustion gases, with the assembly having an internal configuration preventing convective outflow of flue-heated air through the housing dilution air inlet during standby periods of the water heater.

摘要翻译： 燃料热水器具有牵引引风机组件，其具有壳体，该壳体具有用于接收从热水器排出的热燃烧气体的入口和用于排出燃烧气体的出口。 壳体内的常闭阻尼器构件可通过由组件的通风机风扇部分的操作产生的流体压力而打开。 当阻尼器处于打开位置时，风扇通过外壳出口排出接收的燃烧气体。 当风门关闭时，防止通过烟道加热空气的外壳出口的对流流出。 在组件的替代实施例中，风扇还可以吸入冷却风扇电动机和排出的燃烧气体的稀释空气，其中组件具有内部配置，防止烟道热空气在待机期间通过壳体稀释空气入口的对流流出 热水器的时期。