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    TYPE A2 BOTULINUM TOXIN PREPARATION
    1.
    发明申请
    TYPE A2 BOTULINUM TOXIN PREPARATION 审中-公开
    A2型BOTULINUM毒素制剂

    公开(公告)号：US20110033431A1

    公开(公告)日：2011-02-10

    申请号：US12935769

    申请日：2009-03-31

    申请人： Shinji Nakahira ,  Yasushi Torii ,  Yoshitaka Goto ,  Miho Shinmura ,  Satomi Munechika ,  Sachio Okuda ,  Shunji Kozaki

    发明人： Shinji Nakahira ,  Yasushi Torii ,  Yoshitaka Goto ,  Miho Shinmura ,  Satomi Munechika ,  Sachio Okuda ,  Shunji Kozaki

    IPC分类号： A61K35/74 ,  A61P21/00 ,  C12N1/20 ,  C07K14/33

    CPC分类号： A61K38/164 ,  A61K38/4893 ,  Y02A50/469

    摘要： A pharmaceutical preparation for use in a patient who has a neutralizing antibody to a botulinum toxin from type A1 Clostridium botulinum (type A1 botulinum toxin), said preparation comprising as an active ingredient 150 kDa type A neurotoxin from type A2 Clostridium botulinum (A2 NTX); a medicament for treating a disease with muscle overactivity for use in a patient who has a neutralizing antibody to a type A1 botulinum toxin, said medicament comprising as an active ingredient said A2 NTX; a method for treating a patient who has a neutralizing antibody to a type A1 botulinum toxin, said method comprising administering said A2 NTX to the patient; and a method for use of A2 NTX in a patient who has said neutralizing antibody. In accordance with the present invention, a problem can be solved of decrease in clinical response caused by a neutralizing antibody to a type A1 botulinum toxin produced when a patient is treated with a pharmaceutical preparation comprising a type A1 botulinum toxin.

    摘要翻译： 一种用于患有来自A1型肉毒毒素（A1型肉毒杆菌毒素）的肉毒毒素中和抗体的患者的药物制剂，所述制剂包含来自A2型肉毒毒素（A2NTX）的150kDa A型神经毒素作为活性成分， ; 用于治疗患有肌肉过度活动的疾病的药物，所述疾病用于患有A1型肉毒杆菌毒素的中和抗体的患者，所述药物包含所述A2NXX的活性成分; 用于治疗对A1型肉毒杆菌毒素具有中和抗体的患者的方法，所述方法包括向患者施用所述A2NXX; 以及在具有所述中和抗体的患者中使用A2NTX的方法。 根据本发明，当患者用包含A1型肉毒杆菌毒素的药物制剂治疗时，可以解决由中和抗体对产生的A1型肉毒杆菌毒素引起的临床反应降低的问题。