公开(公告)号：US20060088583A1

公开(公告)日：2006-04-27

申请号：US11180982

申请日：2005-07-12

申请人： Shinji Takeoka ,  Eishun Tsuchida ,  Hiromi Sakai ,  Yuji Teramura ,  Tomoyasu Atoji

发明人： Shinji Takeoka ,  Eishun Tsuchida ,  Hiromi Sakai ,  Yuji Teramura ,  Tomoyasu Atoji

IPC分类号： A61K38/42 ,  A61K31/198 ,  A61K9/127

CPC分类号： A61K9/0026 ,  A61K31/198 ,  A61K38/42 ,  A61K2300/00

摘要： The present invention provides an agent containing L-tyrosine that prevents methemoglobin formation, and a vesicle comprising the above agent for preventing methemoglobin formation. More specifically, the present invention provides an oxygen infusion preparation suitable for long-term storage, which prevents an increase in methemoglobin content as a result of oxidation of hemoglobin or the like encapsulated in an vesicle having a lipid bilayer membrane structure.

摘要翻译： 本发明提供含有防止高铁血红蛋白形成的L-酪氨酸的试剂，以及包含上述用于预防高铁血红蛋白形成的试剂的囊泡。 更具体地说，本发明提供一种适于长期储存的氧气输注制剂，其防止由于包封在具有脂质双层膜结构的囊泡中的血红蛋白等的氧化而导致的高铁血红蛋白含量增加。

公开(公告)号：US06967020B2

公开(公告)日：2005-11-22

申请号：US10927047

申请日：2004-08-27

申请人： Eishun Tsuchida ,  Shinji Takeoka ,  Yuji Teramura ,  Tomoyasu Atoji

发明人： Eishun Tsuchida ,  Shinji Takeoka ,  Yuji Teramura ,  Tomoyasu Atoji

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K31/047 ,  A61K31/19 ,  A61K31/198 ,  A61K31/498 ,  A61K31/7048 ,  A61K38/42 ,  A61P7/00 ,  A61P7/08 ,  A61P43/00 ,  A61K38/44 ,  A61K9/127

CPC分类号： A61K9/0026 ,  A61K9/5068 ,  A61K31/047 ,  A61K31/19 ,  A61K31/198 ,  A61K31/498 ,  A61K31/7048 ,  A61K38/42 ,  A61K2300/00

摘要： An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.

摘要翻译： 氧载体系包括包含血红蛋白的血红蛋白囊泡的人造氧载体和囊泡中标准电极电位为0.05V〜0.56V（相对于标准氢电极）的中间电子介体，以及添加至 当包封在血红蛋白囊泡中的血红蛋白被氧化成高铁血红蛋白时，血红蛋白囊泡的外部水相降低高铁血红蛋白。 还原剂作为活性成分具有至少一种选自硫醇化合物和还原糖的化合物。

公开(公告)号：US20050025757A1

公开(公告)日：2005-02-03

申请号：US10927047

申请日：2004-08-27

申请人： Eishun Tsuchida ,  Shinji Takeoka ,  Yuji Teramura ,  Tomoyasu Atoji

发明人： Eishun Tsuchida ,  Shinji Takeoka ,  Yuji Teramura ,  Tomoyasu Atoji

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K31/047 ,  A61K31/19 ,  A61K31/198 ,  A61K31/498 ,  A61K31/7048 ,  A61K38/42 ,  A61P7/00 ,  A61P7/08 ,  A61P43/00 ,  A61K38/44 ,  A61K9/127

CPC分类号： A61K9/0026 ,  A61K9/5068 ,  A61K31/047 ,  A61K31/19 ,  A61K31/198 ,  A61K31/498 ,  A61K31/7048 ,  A61K38/42 ,  A61K2300/00

摘要： An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.

公开(公告)号：US06483527B2

公开(公告)日：2002-11-19

申请号：US09785182

申请日：2001-02-20

申请人： Tamotsu Kaneko ,  Yoshiharu Irei ,  Jun Nakao ,  Yasunori Omori ,  Takayuki Miyamoto ,  Isao Matsuoka ,  Yuji Teramura

发明人： Tamotsu Kaneko ,  Yoshiharu Irei ,  Jun Nakao ,  Yasunori Omori ,  Takayuki Miyamoto ,  Isao Matsuoka ,  Yuji Teramura

IPC分类号： B41J2435

CPC分类号： G03G15/0194 ,  G03G2215/0119

摘要： An image forming apparatus includes a plurality of image bearing components and a plurality of image writing units for writing an image on each of the image bearing components. The apparatus also includes a frame for supporting the plurality of the image bearing components and the plurality of image writing units. The frame has a plurality a of first holding parts for holding both ends of each of the image bearing components and a plurality of second holding parts for holding both ends of each of the image writing units.

摘要翻译： 图像形成装置包括多个图像承载部件和用于在每个图像承载部件上写入图像的多个图像写入单元。 该装置还包括用于支撑多个图像承载部件和多个图像写入单元的框架。 框架具有用于保持每个图像承载部件的两端的多个第一保持部分和用于保持每个图像写入单元的两端的多个第二保持部分。