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公开(公告)号：US4847074A
公开(公告)日：1989-07-11
申请号：US220923
申请日：1988-07-18
申请人： Shinkichi Hatae , Kazuo Nakashima
发明人： Shinkichi Hatae , Kazuo Nakashima
CPC分类号： A61K8/738 , A61K8/498 , A61Q19/02 , Y10S514/844
摘要： A whitening cosmetic comprises kojic acid and cyclodextrins in addition to cosmetic base materials. The kojic acid may be included in cyclodextrins before being incorporated into the cosmetic. The cosmetic has an improved stability against coloring with the passage of time and an enhance whitening effect. The cosmetic can be a toilet lotion, a cosmetic cream, a milky lotion, a pack, etc., for application to human skin.
摘要翻译： 美白化妆品除了化妆品基材外，还包括曲酸和环糊精。 在加入化妆品之前，曲酸可以包括在环糊精中。 化妆品随着时间的推移具有改善的着色稳定性和增强美白效果。 化妆品可以是用于人体皮肤的卫生间洗剂，化妆品霜，乳液，包装等。
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2.发明授权
公开(公告)号：US4919921A
公开(公告)日：1990-04-24
申请号：US248684
申请日：1988-09-23
申请人： Shinkichi Hatae
发明人： Shinkichi Hatae
摘要： Compositions for topical use having melanin synthesis-inhibiting activity comprising kojic acid or its esters and vitamin C or its derivatives. The compositions have excellent human skin-whitening effect and anti-suntan effect.
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公开(公告)号：US4891361A
公开(公告)日：1990-01-02
申请号：US198637
申请日：1988-05-18
申请人： Shinkichi Hatae
发明人： Shinkichi Hatae
CPC分类号： A61K31/35
摘要： Drugs containing, as an effective ingredient, kojic acid or kojic acid/.beta.-cyclodextrin inclusion complex are effective in preventing elastosis in an animal test using Spraguex-Dawley rats. The drugs also have powerful action to inhibit the formation of melanin, and show an outstanding color fading effect in a culture test using mouse melanoma B16 cells. The drugs have very low toxicity and are externally applied in the form of an ointment, cream, emulsion, pack or solution.
摘要翻译： 含有作为有效成分的曲酸或曲酸/β-环糊精包合物的药物在使用Spraguex-Dawley大鼠的动物试验中有效预防弹性变形。 该药物还具有抑制黑色素形成的强大作用，并且在使用小鼠黑素瘤B16细胞的培养试验中显示出优异的褪色效果。 这些药物毒性非常低，并以外用药膏，奶油，乳剂，包装或溶液的形式使用。
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