公开(公告)号：US4855311A

公开(公告)日：1989-08-08

申请号：US183617

申请日：1988-04-19

申请人： Shinobu Iriuchijima ,  Hirohiko Kobayashi ,  Takahito Masuda ,  Shunnosuke Watanabe ,  Hiroshi Tabata

发明人： Shinobu Iriuchijima ,  Hirohiko Kobayashi ,  Takahito Masuda ,  Shunnosuke Watanabe ,  Hiroshi Tabata

IPC分类号： A01N43/80 ,  C07D275/06

CPC分类号： C07D275/06 ,  A01N43/80

摘要： Derivatives of benzoisothiazole oxime which exhibit marked effect when used in plant protection agents for control of fungi and bacteria. They are of particular utility for the prevention of rice blast. The derivatives of benzothiazole oxime, according to this invention, are represented by the following general formula (I): ##STR1## wherein R.sub.1 is an alkyl group, and R.sub.2 is an alkyl, alkenyl, alkoxyalkyl or alkoxycarbonyl group, where R.sub.1 and R.sub.2 may be coupled together to form an alkylene chain.

摘要翻译： 当用于控制真菌和细菌的植物保护剂时，苯并异噻唑肟的衍生物显示出显着的效果。 它们特别适用于防止稻瘟病。 根据本发明的苯并噻唑肟的衍生物由以下通式（I）表示：其中R1是烷基，R2是烷基，烯基，烷氧基烷基或烷氧基羰基，其中R1 并且R 2可以连接在一起以形成亚烷基链。

公开(公告)号：US4849438A

公开(公告)日：1989-07-18

申请号：US198296

申请日：1988-05-25

申请人： Shinobu Iriuchijima ,  Nobuo Onodera ,  Shunnosuke Watanabe ,  Hiroshi Tabata

发明人： Shinobu Iriuchijima ,  Nobuo Onodera ,  Shunnosuke Watanabe ,  Hiroshi Tabata

IPC分类号： A01N43/80 ,  C07D275/06

CPC分类号： A01N43/80

摘要： 1,2-benzoisothiazol-3(2H)-one, 1,1-dioxide, ion(1-),2-hydroxy-N,N,N-trimethyl-ethanaminium represented by the following formula (I): ##STR1## is found to have great utility as an effective component in plant protection agents for control of fungi and bacteria. By the use of the compound, diseases or blights of plants can be effectively prevented.

摘要翻译： 由下式（I）表示的1,2-苯并异噻唑-3（2H） - 酮，1,1-二氧化物，离子（1-），2-羟基-N，N，N-三甲基 - 乙胺： [I]被发现作为控制真菌和细菌的植物保护剂中的有效成分具有很大的效用。 通过使用化合物，可以有效地防止植物的疾病或病害。

公开(公告)号：US4686296A

公开(公告)日：1987-08-11

申请号：US889428

申请日：1986-07-22

申请人： Shinobu Iriuchijima ,  Hirohiko Kobayashi ,  Kyoji Aoki ,  Takeshi Oda ,  Masayuki Shinoyama ,  Yoshifumi Nosaka

发明人： Shinobu Iriuchijima ,  Hirohiko Kobayashi ,  Kyoji Aoki ,  Takeshi Oda ,  Masayuki Shinoyama ,  Yoshifumi Nosaka

IPC分类号： C07D207/26 ,  C07D207/273 ,  C07D207/12

CPC分类号： C07D207/273

摘要： A process for producing oxiracetam (4-hydroxy-2-oxo-1-pyrrolidineacetamide) useful as an agent for improving brain metabolism, under mild conditions and in a single process is provided, this process comprises reacting glycinamide with a butyric acid ester expressed by the formula ##STR1## wherein A represents a halogen atom or an epoxy group, B represents hydroxyl group, but when A is an epoxy group, A and B together form an epoxy group, and R represents an alkyl group.

摘要翻译： 提供了用于在温和条件下和单一方法中用作改善脑代谢的药物的奥拉西坦（4-羟基-2-氧代-1-吡咯烷乙酰胺）的方法，该方法包括使甘氨酰胺与丁酸酯 式中，A表示卤素原子或环氧基，B表示羟基，但当A为环氧基时，A和B一起形成环氧基，R表示烷基。

公开(公告)号：US5789572A

公开(公告)日：1998-08-04

申请号：US864962

申请日：1997-05-29

申请人： Yutaka Ida ,  Satoshi Kikuchi ,  Shinobu Iriuchijima

发明人： Yutaka Ida ,  Satoshi Kikuchi ,  Shinobu Iriuchijima

IPC分类号： C07D307/33 ,  B01J25/00 ,  C07C29/149 ,  C07C31/24 ,  C07H3/02 ,  C07H1/00 ,  C07H15/02

CPC分类号： C07H3/02

摘要： Proposed is a novel synthetic route for the preparation of 1,4-anhydro-2-deoxy-D-erythropentitol, which is a useful material in the synthesis of antibiotics, starting from 2-deoxy-D-ribose via 2-deoxy-D-erythropentitol as an intermediate. 2-Deoxy-D-erythropentitol can be prepared by the hydrogenation of 2-deoxy-D-ribose with Raney nickel as the hydrogenating catalyst in a high efficiency and at low costs as compared with the prior art methods using, for example, sodium borohydride as the hydrogenating agent. 2-Deoxy-D-erythropentitol is subjected to a dehydration cyclization reaction to be converted into 1,4-anhydro-2-deoxy-D-erythropenti-tol under a substantially anhydrous condition which is accomplished by heating a reaction mixture containing 2-deoxy-D-erythropentitol suspended in an organic solvent capable of forming an azeotropic mixture with water such as toluene under reflux so as to azeotropically remove the water condensate.

摘要翻译： 提出了一种用于制备1,4-脱水-2-脱氧-D-赤藓糖醇的新型合成途径，它是抗生素合成中的有用材料，从2-脱氧-D-核糖通过2-脱氧-D 作为中间体。 与现有技术方法相比，2-脱氧-D-赤红葡萄糖可以通过用阮内镍作为氢化催化剂以高效率和低成本氢化来制备，使用例如硼氢化钠 作为氢化剂。 将脱氧-D-红血球醇进行脱水环化反应，在基本无水条件下转化为1,4-脱水-2-脱氧-D-红胸肉汤，其通过加热含有2-脱氧的反应混合物 D-赤式甘油二异氰酸酯悬浮在能够与水如甲苯在回流下形成共沸混合物的有机溶剂中，以共沸除去水的缩合物。