公开(公告)号：US5162553A

公开(公告)日：1992-11-10

申请号：US717813

申请日：1991-06-19

申请人： Shinro Setoguchi ,  Mineo Tsuruda ,  Chiaki Kitami ,  Tsutomu Yamanaka

发明人： Shinro Setoguchi ,  Mineo Tsuruda ,  Chiaki Kitami ,  Tsutomu Yamanaka

IPC分类号： C07D311/22 ,  C07D493/04

CPC分类号： C07D493/04 ,  C07D311/22

摘要： The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereometric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.

摘要翻译： 本发明提供了一种工业上有价值的制备光学活性3,4-二氢-3,4-环氧-2H-1-苯并吡喃化合物的方法，其可用作具有抗高血压，冠状动脉血流的光学活性苯并吡喃化合物的起始物质 - 增加活性等，并且还提供了可用作所述环氧化合物的中间体的3-卤代-4-羟基-2H-1-苯并吡喃化合物的非对映酯化合物。

公开(公告)号：US5066816A

公开(公告)日：1991-11-19

申请号：US486100

申请日：1990-02-28

申请人： Shinro Setoguchi ,  Mineo Tsuruda ,  Chiaki Kitami ,  Tsutomu Yamanaka

发明人： Shinro Setoguchi ,  Mineo Tsuruda ,  Chiaki Kitami ,  Tsutomu Yamanaka

IPC分类号： C07D311/22 ,  C07D493/04

CPC分类号： C07D493/04 ,  C07D311/22

摘要： The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereomeric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.

公开(公告)号：US4122178A

公开(公告)日：1978-10-24

申请号：US692395

申请日：1976-06-03

申请人： Gen Hasegawa ,  Takanori Oe ,  Chiaki Kitami

发明人： Gen Hasegawa ,  Takanori Oe ,  Chiaki Kitami

IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P25/04 ,  C07D213/38 ,  C07D233/02 ,  C07D239/42 ,  C07D295/084 ,  C07D295/10 ,  C07D333/20 ,  C07D401/06 ,  C07D295/04

CPC分类号： C07D295/092 ,  C07C317/00

摘要： Piperazine compounds useful as analgesics, and having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or CF.sub.3 ; R.sup.3 is hydrogen, hydroxyl, an optionally substituted phenyl (e.g. phenyl, halo-phenyl, C.sub.1-4 alkyl-phenyl, C.sub.1-4 alkoxy-phenyl or CF.sub.3 -phenyl), pyridyl, 2-thienyl or 2-pyrimidinyl; m is 2 or 3; and n is 0, 1 or 2, and pharmaceutically acceptable acid addition salts thereof are disclosed.

摘要翻译： 可用作止痛剂的哌嗪化合物，具有下式：其中R 1和R 2各自为氢，卤素，C 1-4烷基，C 1-4烷氧基或CF 3; R 3是氢，羟基，任选取代的苯基（例如苯基，卤代 - 苯基，C 1-4烷基 - 苯基，C 1-4烷氧基 - 苯基或CF 3 - 苯基），吡啶基，2-噻吩基或2-嘧啶基; m为2或3; 和n为0,1或2，并且其药学上可接受的酸加成盐被公开。